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This approach affords diverse iminoisocoumarin-braced macrocycles with 13- to 28-membered rings bearing various functional groups in good yields with excellent regioselectivity under mild electrooxidation conditions. Mechanistic studies, including isolation and characterization of a key Rh(I) sandwich intermediate, along with cyclic voltammetry analysis, provide evidence for a rhodium(III\/I) catalytic regime.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03248","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:02:37Z","timestamp":1789635757000},"page":"12224-12230","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical\nSynthesis of Macrocyclic Iminoisocoumarins\nby Rh-Catalyzed Intramolecular Vinylic C\u2013H Activation\/Heterocyclization"],"prefix":"10.1021","volume":"28","author":[{"given":"Qing-Xi","family":"Zhang","sequence":"first","affiliation":[{"name":"Henan Normal University , , , ,","place":["Xinxiang, Henan, China, 453007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Normal University , , , ,","place":["Xinxiang, Henan, China, 453007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qin","family":"Hao","sequence":"additional","affiliation":[{"name":"Henan Normal University , , , ,","place":["Xinxiang, Henan, China, 453007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4734-5391","authenticated-orcid":true,"given":"Qi-Liang","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Normal University , , , ,","place":["Xinxiang, Henan, China, 453007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-4524","authenticated-orcid":true,"given":"Hai-Ming","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan Normal University , , , ,","place":["Xinxiang, Henan, China, 453007"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026100208363278000_cit1a","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00044-025-03506-1","article-title":"Macrocyclization\nin Medicinal Chemistry: Updated Strategies and Applications","volume":"35","author":"Darlami","year":"2026","journal-title":"Med. 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