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By employing redox-active N-hydroxyphthalimide (NHPI) esters as alkyl radical precursors, the first photocatalytic method capable of directly converting readily available commercial alkynes, simple amides, and NHPI esters into alkylated enamides was established. The developed protocol exhibits broad functional group compatibility, enabling the late-stage functionalization of complex molecular architectures.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03274","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:16:01Z","timestamp":1788452161000},"page":"11649-11654","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic\nPhotoredox and Copper Catalysis for 1,2-Alkylamination\nof Alkynes"],"prefix":"10.1021","volume":"28","author":[{"given":"Xinyu","family":"Long","sequence":"first","affiliation":[{"name":"West China Hospital, Sichuan University , , 37 Guoxue Alley , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-2256","authenticated-orcid":true,"given":"Chengming","family":"Li","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , 37 Guoxue Alley , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ren","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , 37 Guoxue Alley , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Li","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , 37 Guoxue Alley , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-620X","authenticated-orcid":true,"given":"Kaizhi","family":"Li","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , 37 Guoxue Alley , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026091809424764500_cit1a","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.1021\/cr050051k","article-title":"Stereocontrolled Synthesis of Tetrasubstituted Olefins","volume":"107","author":"Flynn","year":"2007","journal-title":"Chem. 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