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Control experiments and density functional theory calculations indicate that the I2-catalyzed aerobic oxidation reaction proceeds via generation of the iodoalkyl radical, coupling with molecular oxygen, hydrogen atom abstraction from dichloromethane, and C\u2013I bond cleavage to deliver the corresponding \u03b1-keto phosphonates. This metal-free protocol features mild reaction conditions, operational simplicity, and scalability. Moreover, it reveals a new reaction mode of \u03b1-diazophosphonates.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03308","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:40:50Z","timestamp":1788298850000},"page":"11309-11314","source":"Crossref","is-referenced-by-count":0,"title":["One-Pot Reaction\nof \u03b1-Diazo Phosphonates\nvia Iodine-Catalyzed Cascade Radical Aerobic Oxidation and C\u2013P\nBond Cleavage"],"prefix":"10.1021","volume":"28","author":[{"given":"Jierui","family":"Deng","sequence":"first","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-1935","authenticated-orcid":true,"given":"Haibo","family":"Mei","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-0991","authenticated-orcid":true,"given":"Jorge","family":"Escorihuela","sequence":"additional","affiliation":[{"name":"Universitat de Vale\u0300ncia , , Avenida Vicente Andre\u0301s Estelle\u0301s s\/n , , ,","place":["Burjassot, Valencia, Spain, 46100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana","family":"Pajkert","sequence":"additional","affiliation":[{"name":"Constructor University Bremen gGmbH , , Campus Ring 1 , ,","place":["Bremen, Germany, 28759"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd-Volker","family":"Ro\u0308schenthaler","sequence":"additional","affiliation":[{"name":"Constructor University Bremen gGmbH , , Campus Ring 1 , ,","place":["Bremen, Germany, 28759"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-0764","authenticated-orcid":true,"given":"Jianlin","family":"Han","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026091110070558700_cit1a","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1021\/acschembio.6b00810","article-title":"Diazo Compounds:\nVersatile Tools for Chemical Biology","volume":"11","author":"Mix","year":"2016","journal-title":"ACS Chem.\nBiol."},{"key":"2026091110070558700_cit1b","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1039\/c1np00031d","article-title":"Natural\nproducts containing a diazo group","volume":"28","author":"Nawrat","year":"2011","journal-title":"Nat. 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