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The synthesis of peptide sequences containing dehydroamino acids remains nontrivial and only a few chemical methods allow for their incorporation. We report the conversion of amino acid residues bearing \u03b2-thiols into dehydroamino acids through the treatment of unprotected peptides and proteins with cyanamide under mild, fully aqueous conditions that are compatible with commonly used buffer salts.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03312","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:13:23Z","timestamp":1788412403000},"page":"11303-11308","source":"Crossref","is-referenced-by-count":0,"title":["Cyanamide-Induced\nDesulfhydration Enables Access to\n\u03b1,\u03b2-Dehydropeptides"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7467-0641","authenticated-orcid":true,"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"University of Illinois at Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61822"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0684-8832","authenticated-orcid":true,"given":"Songyi","family":"Xue","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61822"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0694-219X","authenticated-orcid":true,"given":"Ryan","family":"Moreira","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61822"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-7071","authenticated-orcid":true,"given":"Wilfred A.","family":"van der Donk","sequence":"additional","affiliation":[{"name":"University of Illinois at Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61822"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"2","key":"2026091110062391100_cit1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1039\/D3NP00041A","article-title":"Dehydroamino acid residues in bioactive\nnatural products","volume":"41","author":"Wang","year":"2024","journal-title":"Nat. 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Biomol. Chem."},{"issue":"23","key":"2026091110062391100_cit37","doi-asserted-by":"publisher","first-page":"6188","DOI":"10.1021\/acs.orglett.6b03246","article-title":"Synthesis\nand bioactivity of diastereomers of the virulence lanthipeptide cytolysin","volume":"18","author":"Mukherjee","year":"2016","journal-title":"Org. Lett."},{"issue":"19","key":"2026091110062391100_cit38","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.1021\/ja4014024","article-title":"Chemical\nsynthesis of the lantibiotic lacticin 481\nreveals the importance of lanthionine stereochemistry","volume":"135","author":"Knerr","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"13","key":"2026091110062391100_cit39","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1021\/ol0507930","article-title":"Versatile\nand stereoselective syntheses of orthogonally\nprotected beta-methylcysteine and beta-methyllanthionine","volume":"7","author":"Narayan","year":"2005","journal-title":"Org. 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