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Herein, we report an iron photocatalytic platform based on ligand-to-metal charge transfer (LMCT) for visible-light-induced desulfonylation of sulfonamides. Using a simple Fe(OTs)3\/TBAOx system, a variety of heteroaryl, diarylamine, and amide-derived sulfonamides underwent efficient N\u2013S bond cleavage without stoichiometric metal reductants. The method exhibits broad functional-group tolerance and enables rapid deprotection of an AZD4604 intermediate within 2 h.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03324","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:19:56Z","timestamp":1788452396000},"page":"11683-11687","source":"Crossref","is-referenced-by-count":0,"title":["Iron-Catalyzed\nLigand-to-Metal Charge Transfer (LMCT)\nDesulfonylation of Sulfonamides under Visible Light"],"prefix":"10.1021","volume":"28","author":[{"given":"Meng-Yuan","family":"Cao","sequence":"first","affiliation":[{"name":"Liaocheng University , , ,","place":["Liaocheng, P. R. China, 252059"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Hang","family":"An","sequence":"additional","affiliation":[{"name":"Chizhou University , , ,","place":["Chizhou, P. R. China, 247000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Lu\u0308","sequence":"additional","affiliation":[{"name":"Liaocheng University , , ,","place":["Liaocheng, P. R. China, 252059"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Xi","family":"Peng","sequence":"additional","affiliation":[{"name":"Liaocheng University , , ,","place":["Liaocheng, P. R. China, 252059"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-1191","authenticated-orcid":true,"given":"Qian-Li","family":"Li","sequence":"additional","affiliation":[{"name":"Liaocheng University , , ,","place":["Liaocheng, P. R. China, 252059"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-3269","authenticated-orcid":true,"given":"Yu-Long","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan University of Science and Engineering , , , ,","place":["Zigong, Sichuan, P. R. 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J."},{"key":"2026091809411384600_cit3","doi-asserted-by":"publisher","first-page":"6373","DOI":"10.1016\/0040-4039(95)01316-A","article-title":"2- and 4-Nitrobenzenesulfonamides:\nExceptionally versatile means for preparation of secondary amines\nand protection of amines","volume":"36","author":"Fukuyama","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"2026091809411384600_cit4","doi-asserted-by":"publisher","first-page":"8755","DOI":"10.1021\/ja039674a","article-title":"Development of a Catalytic\nElectron Transfer System Mediated by Transition Metal Ate Complexes:\nApplicability and Tunability of Electron-Releasing Potential for Organic\nTransformations","volume":"126","author":"Uchiyama","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"2026091809411384600_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/asia.70362","article-title":"Visible-Light Induced\nRadical Cyclization of N-Allylbenzamide with \u03b1-Carbonyl Alkyl\nBromide for Direct Construction of Dihydroisoquinolones","volume":"20","author":"Shi","year":"2025","journal-title":"Chem.\u2500Asian J."},{"key":"2026091809411384600_cit6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1021\/ol802243d","article-title":"Instantaneous Deprotection of Tosylamides and Esters\nwith SmI2\/Amine\/Water","volume":"11","author":"Ankner","year":"2009","journal-title":"Org. Lett."},{"key":"2026091809411384600_cit7","doi-asserted-by":"publisher","first-page":"13423","DOI":"10.1021\/acs.joc.7b02507","article-title":"Chemoselective Deprotection\nof Sulfonamides Under Acidic\nConditions: Scope, Sulfonyl Group Migration, and Synthetic Applications","volume":"82","author":"Javorskis","year":"2017","journal-title":"J. Org. Chem."},{"key":"2026091809411384600_cit8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1021\/jo00863a042","article-title":"New synthesis of L-2-amino-3-oxalylaminopropionic acid,\nthe Lathyrus sativus neurotoxin","volume":"41","author":"Haskell","year":"1976","journal-title":"J. Org. Chem."},{"key":"2026091809411384600_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2020.152442","article-title":"A NaH-promoted\nN-detosylation reaction of diverse p-toluenesulfonamides","volume":"61","author":"Sun","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"2026091809411384600_cit10","doi-asserted-by":"publisher","first-page":"12087","DOI":"10.1021\/acs.joc.2c01169","article-title":"Reduction of Substituted\nBenzo-Fused Cyclic Sulfonamides with Mg-MeOH: An Experimental and\nComputational Study","volume":"87","author":"Khalifa","year":"2022","journal-title":"J. Org. 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Catal."},{"key":"2026091809411384600_cit18","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41586-020-2131-1","article-title":"Discovery and characterization\nof an acridine radical photoreductant","volume":"580","author":"MacKenzie","year":"2020","journal-title":"Nature"},{"key":"2026091809411384600_cit19","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1021\/acs.orglett.5c01013","article-title":"Reductive\nDesulfonylation of Sulfonamides\nunder Polysulfide Anions Photocatalysis","volume":"27","author":"Feng","year":"2025","journal-title":"Org.\nLett."},{"key":"2026091809411384600_cit20","doi-asserted-by":"publisher","first-page":"5322","DOI":"10.1021\/cr300503r","article-title":"Visible Light Photoredox Catalysis\nwith Transition Metal Complexes: Applications in Organic Synthesis","volume":"113","author":"Prier","year":"2013","journal-title":"Chem. 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