{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:55:20Z","timestamp":1790949320431,"version":"4.1.0"},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A Rh(III)-catalyzed exclusive [4 + 2] cascade cyclization of 2-phenylbenzimidazoles with 3-methylmaleimides for the synthesis of spiro-fused benzimidazoisoquinoline succinimides via C\u2013H activation is reported. The detailed mechanistic study revealed that the reaction proceeds through N-directed C\u2013H activation of 2-phenylbenzimidazole. Subsequent migratory insertion of the rhodium-mediated formation of isomeric maleimide into the Rh\u2013C bond and reductive elimination affords the polycyclic spiro-fused benzimidazoisoquinoline succinimide<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03335","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:02:08Z","timestamp":1790013728000},"page":"12271-12275","source":"Crossref","is-referenced-by-count":0,"title":["Rh(III)-Catalyzed\n[4 + 2] Spiroannulation of 2-Phenylbenzimidazoles\nwith Isomerizable 3-Methylmaleimides: Synthesis of Spiro-Fused\nBenzimidazoisoquinoline Succinimides"],"prefix":"10.1021","volume":"28","author":[{"given":"Wei-Jung","family":"Chiu","sequence":"first","affiliation":[{"name":"National Yang-Ming Chiao-Tung University , , ,","place":["Hsinchu, Taiwan, 300-10"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Han","family":"Shih","sequence":"additional","affiliation":[{"name":"National Yang-Ming Chiao-Tung University , , ,","place":["Hsinchu, Taiwan, 300-10"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrajeet J.","family":"Barve","sequence":"additional","affiliation":[{"name":"MES Abasaheb Garware College , , , ,","place":["Pune, Maharashtra, India, 411004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-1578","authenticated-orcid":true,"given":"Chung-Ming","family":"Sun","sequence":"additional","affiliation":[{"name":"National Yang-Ming Chiao-Tung University , , ,","place":["Hsinchu, Taiwan, 300-10"]},{"name":"Kaohsiung Medical University , , ,","place":["Kaohsiung, Taiwan, 807-08"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026100208372632900_cit1a","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.2174\/092986707781058805","article-title":"Molecular Hybridization:\nA Useful Tool in the Design of New Drug Prototypes","volume":"14","author":"Viegas-Junior","year":"2007","journal-title":"Curr. 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