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Their structures were determined by spectroscopic analysis and X-ray crystallography. 1\u20135 preferentially inhibited Cav3.1 over other T-type calcium channels, whereas 4 and 5 exhibited state-dependent gating modulation of Cav3.1 and represent a novel class of Cav3.1 allosteric modulators.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03362","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:10Z","timestamp":1789642930000},"page":"12281-12286","source":"Crossref","is-referenced-by-count":0,"title":["1,2-\n                    <i>seco<\/i>\n                    -Bicyclic Polyprenylated\nAcylphloroglucinols as Isoform Selective Inhibitors of T-Type\nCalcium Channels"],"prefix":"10.1021","volume":"28","author":[{"given":"Yu","family":"Zhou","sequence":"first","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gong","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-064X","authenticated-orcid":true,"given":"Yin","family":"Nian","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-104X","authenticated-orcid":true,"given":"Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026100208362788500_cit1","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1021\/acs.chemrev.7b00551","article-title":"Research progress of polycyclic polyprenylated\nacylphloroglucinols","volume":"118","author":"Yang","year":"2018","journal-title":"Chem. 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