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Nevertheless, the facile synthesis of diverse carbon-substituted piperazine derivatives from readily available, structurally simple feedstock chemicals remains a formidable synthetic challenge. Herein, we disclose a modular electrochemical strategy for the efficient synthesis of functionalized piperazine and 1,4-diazepane derivatives. This protocol employs inexpensive and commercially available alkenes as the starting materials. Crucially, the well-designed reaction sequence including anodic oxidation and nucleophilic attack effectively forged the C\u2013N bond formation twice, ultimately delivering the target heterocyclic products. By employing electrons as traceless oxidants, the protocol is endowed with operational simplicity, mild reaction conditions, and broad functional group tolerance.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03409","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:31Z","timestamp":1790974891000},"page":"12878-12883","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical\nCyclization of Alkene with Bisnucleophile\nto Assemble Piperazine\/1,4-Diazepane Scaffolds"],"prefix":"10.1021","volume":"28","author":[{"given":"Zi-Hao","family":"Liao","sequence":"first","affiliation":[{"name":"Central South University , , ,","place":["Changsha, P. R. China, 410083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Central South University , , ,","place":["Changsha, P. R. 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