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Application to aztreonam afforded the first aerobactin\u2013antibiotic conjugates. Monovalent conjugate 3b showed superior activity against hypervirulent Klebsiella pneumoniae KPN234 (MIC = 0.031 \u03bcM), a 16-fold improvement over aztreonam. Competition and iron-dependent activity studies supported aerobactin-pathway-dependent delivery, establishing aerobactin as a viable antibacterial delivery scaffold.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03421","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:02:03Z","timestamp":1788966123000},"page":"11737-11742","source":"Crossref","is-referenced-by-count":0,"title":["Modular Synthesis\nof Aerobactin\u2013Aztreonam Conjugates\nwith Enhanced Activity against Hypervirulent\n                    <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1021","volume":"28","author":[{"given":"Yulin","family":"Zou","sequence":"first","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, P.R. 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