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The operational robustness is underscored by scale-up reactions and versatile postsynthetic transformations. X-ray crystallography verifies a pyramidalized nitrogen center deviating 20\u00b0 from planarity, while thermal racemization experiments establish strong configurational stability. This strategy provides a general platform for developing pyramidalized N\u2013N atropisomers.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03439","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:49:12Z","timestamp":1788454152000},"page":"11750-11756","source":"Crossref","is-referenced-by-count":0,"title":["Remote Generation\nof Pyramidalized N\u2013N Axial\nChirality via a Copper-Catalyzed Friedel\u2013Crafts Reaction"],"prefix":"10.1021","volume":"28","author":[{"given":"Hao","family":"Zhu","sequence":"first","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuaikuai","family":"Xu","sequence":"additional","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-6975","authenticated-orcid":true,"given":"Wenkun","family":"Luo","sequence":"additional","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1585-7261","authenticated-orcid":true,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Qiu","sequence":"additional","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijun","family":"Ming","sequence":"additional","affiliation":[{"name":"Sichuan Police College , ,","place":["Luzhou, China, 646000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1962-7714","authenticated-orcid":true,"given":"Weiwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Changsha University of Science and Technology , , ,","place":["Changsha, China, 410114"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026091809430831400_cit1a","doi-asserted-by":"publisher","first-page":"5384","DOI":"10.1002\/anie.200462661","article-title":"Atroposelective Synthesis of Axially\nChiral Biaryl Compounds","volume":"44","author":"Bringmann","year":"2005","journal-title":"Angew. 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