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Herein, we disclose a nickel-catalyzed regio- and diastereoselective ring-opening reductive coupling of methylenecyclopropanes with aldehydes. The method offers an efficient route to bishomoallylic alcohols under mild conditions with a broad substrate scope (37 examples), good functional group tolerance, and generally high diastereoselectivity.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03444","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:24:30Z","timestamp":1788301470000},"page":"11386-11393","source":"Crossref","is-referenced-by-count":0,"title":["Nickel-Catalyzed\nRegio- and Diastereoselective Ring-Opening\nReductive Coupling of Methylenecyclopropanes with Aldehydes"],"prefix":"10.1021","volume":"28","author":[{"given":"Min","family":"Ou","sequence":"first","affiliation":[{"name":"Hunan Normal University , , ,","place":["Changsha, P. R. 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Chem.\nRes."},{"key":"2026091110065562900_cit2d","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1021\/cr400686j","article-title":"Progress in the Synthesis and Transformations of Alkylidenecyclopropanes\nand Alkylidenecyclobutanes","volume":"114","author":"Brandi","year":"2014","journal-title":"Chem. Rev."},{"key":"2026091110065562900_cit3a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202202160","article-title":"Enantio- and Regioselective\nConstruction of 1,4-Diamines via Cascade Hydroamination of Methylene\nCyclopropanes","volume":"61","author":"Zhou","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026091110065562900_cit3b","doi-asserted-by":"publisher","first-page":"5366","DOI":"10.1021\/jacs.3c12675","article-title":"Enantioselective\nCopper-Catalyzed Ring-Opening Diboration of Arylidenecyclopropanes\nto Access Chiral Skipped 1,4- and 1,3-Diboronates","volume":"146","author":"Zheng","year":"2024","journal-title":"J. Am. Chem. 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Lett."},{"key":"2026091110065562900_cit9a","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/(SICI)1521-3773(19990201)38:3&lt;397::AID-ANIE397&gt;3.0.CO;2-Y","article-title":"Nickel-Catalyzed Homoallylation\nof Aldehydes and Ketones with 1,3-Dienes and Complementary Promotion\nby Diethylzinc or Triethylborane","volume":"38","author":"Kimura","year":"1999","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026091110065562900_cit9b","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1021\/ja0693183","article-title":"Asymmetric Reductive Coupling of\nDienes and Aldehydes Catalyzed by Nickel Complexes of Spiro Phosphoramidites:\nHighly Enantioselective Synthesis of Chiral Bishomoallylic Alcohols","volume":"129","author":"Yang","year":"2007","journal-title":"J. Am. Chem. 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Lett."},{"key":"2026091110065562900_cit11","doi-asserted-by":"publisher","first-page":"11298","DOI":"10.1021\/ja9046894","article-title":"Nickel-Catalyzed Ring-Opening\nHydroacylation\nof Methylenecyclopropanes: Synthesis of \u03b3,\u03b4-Unsaturated Ketones from Aldehydes","volume":"131","author":"Taniguchi","year":"2009","journal-title":"J. Am.\nChem. Soc."},{"key":"2026091110065562900_cit12","doi-asserted-by":"publisher","first-page":"4536","DOI":"10.1021\/ol101838q","article-title":"Nickel-Catalyzed\nRing-Opening Three-Component\nCoupling of Methylenecyclopropane with Aldehydes and Silanes","volume":"12","author":"Ogata","year":"2010","journal-title":"Org. Lett."},{"key":"2026091110065562900_cit13a","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1021\/acs.orglett.3c00185","article-title":"Nickel-Catalyzed Desulfonylative\nReductive Cross-Coupling of Aryl\nSulfones with Aryl Bromides","volume":"25","author":"Huang","year":"2023","journal-title":"Org. 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