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This reaction proceeds via Br\u00f8nsted acid-catalyzed cyclization of N-indole-tethered allenamides with &amp;gt;20:1 dr under mild conditions, while chiral phosphoric acid catalysis installs the C\u2013N axial chirality with high enantioselectivity (up to 98% ee). An ortho-amide directing group and proper choice of catalyst prove crucial for the stereocontrol. Furthermore, divergent derivatizations of the products, particularly elaboration of the vinyl group, highlight the synthetic utility of this protocol.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03458","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:07:14Z","timestamp":1788376034000},"page":"11379-11385","source":"Crossref","is-referenced-by-count":0,"title":["Diastereo- and\nEnantioselective Synthesis of 9-Aryl-1-vinyl-tetrahydro-\u03b2-carbolines\nvia Br\u00f8nsted Acid-Catalyzed Pictet\u2013Spengler Reaction"],"prefix":"10.1021","volume":"28","author":[{"given":"Deyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Wuhan University of Technology , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9760-0251","authenticated-orcid":true,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan University of Technology , , ,","place":["Wuhan, China, 430070"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"2026091110065220900_cit1a","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.1021\/acs.chemrev.0c01306","article-title":"Recent advances in catalytic asymmetric construction of atropisomers","volume":"121","author":"Cheng","year":"2021","journal-title":"Chem. 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