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Herein, we report a general synthesis of these compounds from readily available oxetanyl trichloroacetimidate (OTA) reagents. Friedel\u2013Crafts trapping of oxetanyl carbocations generated from OTAs with inexpensive, biomass-derived 2-methylfuran, followed by selective oxidative cleavage of the resulting intermediates, furnishes a broad range of 3-aryloxetane 3-carboxylic acids. Electron-deficient, -neutral, and -rich arenes are all accommodated.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03485","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:24:18Z","timestamp":1788441858000},"page":"11795-11800","source":"Crossref","is-referenced-by-count":0,"title":["Oxetanyl Trichloroacetimidates Enable a General Synthesis\nof 3-Aryloxetane 3-carboxylic Acids"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2718-4371","authenticated-orcid":true,"given":"Xian","family":"Xiao","sequence":"first","affiliation":[{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-1050","authenticated-orcid":true,"given":"Xiaocheng","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2963-0378","authenticated-orcid":true,"given":"Hai-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026091809423669200_cit1","doi-asserted-by":"publisher","first-page":"7736","DOI":"10.1002\/anie.200602343","article-title":"Oxetanes as Promising\nModules in Drug Discovery","volume":"45","author":"Wuitschik","year":"2006","journal-title":"Angew. 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