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The mechanistic studies revealed that the reaction involved a gold(I)-catalyzed 5-endo-dig cyclization of the o-alkynyl anilines to indoles, TBN-mediated nitrosation of indoles, and gold(I)-catalyzed C\u2013C bond cleavage over three steps. The present method features a broad substrate scope, good functional group compatibility, and efficient and highly regioselective C\u2261C bond cleavage, with the amino group serving as a directing group and TBN as the nitrogen source of nitriles.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03520","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:02:42Z","timestamp":1790154162000},"page":"12401-12406","source":"Crossref","is-referenced-by-count":0,"title":["Gold(I)-Catalyzed\nRegioselective C\u2261C Bond Cleavage\nof\n                    <i>o<\/i>\n                    -Alkynyl Anilines with\n                    <i>tert<\/i>\n                    -Butyl Nitrite to Prepare 2-Aminobenzonitriles"],"prefix":"10.1021","volume":"28","author":[{"given":"Yuan-Yuan","family":"Fan","sequence":"first","affiliation":[{"name":"Guilin Medical University , , 1 Zhi Yuan Road , ,","place":["Guilin, China, 541199"]},{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Rong","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guilin Medical University , , 1 Zhi Yuan Road , ,","place":["Guilin, China, 541199"]},{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoao","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Changsha Medical University , , ,","place":["Changsha, China, 410219"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yun","family":"Huang","sequence":"additional","affiliation":[{"name":"Guilin Medical University , , 1 Zhi Yuan Road , ,","place":["Guilin, China, 541199"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-2249","authenticated-orcid":true,"given":"Dong-Liang","family":"Mo","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-4945","authenticated-orcid":true,"given":"Xiao-Pan","family":"Ma","sequence":"additional","affiliation":[{"name":"Guilin Medical University , , 1 Zhi Yuan Road , ,","place":["Guilin, China, 541199"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026100208362703100_cit1a","doi-asserted-by":"publisher","first-page":"100294","DOI":"10.1016\/j.ejmcr.2025.100294","article-title":"Molecules\nwith alkyne fragment in\nmedicinal chemistry: The path from neurotoxins to drugs","volume":"15","author":"Zelisko","year":"2025","journal-title":"Eur. 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Lett."},{"key":"2026100208362703100_cit17d","doi-asserted-by":"publisher","first-page":"12588","DOI":"10.1021\/acs.joc.5b01666","article-title":"Rhodium(III)-Catalyzed Direct Cyanation of Aromatic C\u2013H Bond\nto Form 2-(Alkylamino)benzonitriles Using N-Nitroso\nas Directing Group","volume":"80","author":"Dong","year":"2015","journal-title":"J. Org. Chem."},{"key":"2026100208362703100_cit18","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1021\/acs.orglett.8b01070","article-title":"Palladium-Catalyzed\nThree-Component\nTandem Process: One-Pot Assembly of Quinazolines","volume":"20","author":"Hu","year":"2018","journal-title":"Org. Lett."},{"key":"2026100208362703100_cit19","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.ejmech.2018.03.076","article-title":"An overview\nof quinazolines: Pharmacological significance\nand recent developments","volume":"151","author":"Alagarsamy","year":"2018","journal-title":"Eur. J. Med. 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