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This protocol circumvents the pre-installation and removal of N-directing groups, enabling direct C2\u2013H acylation under mild, open-air conditions. Utilizing acid anhydrides as acylating agents, the reaction shows good functional group tolerance and provides a highly step-economical platform to biologically relevant 2-acylindoles, as demonstrated by the streamlined, single-step synthesis of a platelet-derived growth factor receptor (PDGFR) kinase inhibitor.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03562","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:01:11Z","timestamp":1789048871000},"page":"12040-12045","source":"Crossref","is-referenced-by-count":0,"title":["Direct C2 Acylation\nof Free (\n                    <i>N<\/i>\n                    \u2013H)\nIndoles Enabled by Pd(II)\/Norbornene Cooperative Catalysis"],"prefix":"10.1021","volume":"28","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Hubei University of Science and Technology , , ,","place":["Xianning, P. R. China, 437100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry , , ,","place":["Kunming, P. R. China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei University of Science and Technology , , ,","place":["Xianning, P. R. China, 437100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei University of Science and Technology , , ,","place":["Xianning, P. R. China, 437100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaishuai","family":"Hou","sequence":"additional","affiliation":[{"name":"Hubei University of Science and Technology , , ,","place":["Xianning, P. R. 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Ed."},{"key":"2026092510103639000_cit24","doi-asserted-by":"publisher","first-page":"4949","DOI":"10.1016\/S0040-4039(00)85756-1","article-title":"La transformation\nd\u2019indolines\nen indoles et d\u2019autres reactions apparentees","volume":"23","author":"Barton","year":"1982","journal-title":"Tetrahedron Lett."},{"key":"2026092510103639000_cit25","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1002\/anie.201813699","article-title":"Palladium\/Norbornene-Catalyzed\nIndenone Synthesis from Simple Aryl Iodides: Concise Syntheses of\nPauciflorol F and Acredinone A","volume":"58","author":"Liu","year":"2019","journal-title":"Angew. Chem.\nInt. Ed."},{"key":"2026092510103639000_cit26","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1021\/jm010988n","article-title":"Bis(1H-2-indolyl)methanones as a Novel\nClass of Inhibitors of the Platelet-Derived Growth Factor Receptor\nKinase","volume":"45","author":"Mahboobi","year":"2002","journal-title":"J. Med. 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