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While lactams and indolinones have been accessed using alkenes and arenes as appendages via this strategy, the dearomative functionalization of arenes remains unexplored. This work demonstrates a photocatalyst-free, visible light-mediated blueprint for the remote functionalization of arenes in tandem with a strain-release framework. Nitrosamines are utilized as versatile reagents for installing sulfonamides and oximes, leading to intricately designed 3D spirocyclic structures bearing medicinally relevant functionalities.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03574","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:01:53Z","timestamp":1790125313000},"page":"12419-12424","source":"Crossref","is-referenced-by-count":0,"title":["Visible Light-Mediated\nDearomative Remote Functionalization\nof Arenes via a Tandem Strain-Release Spirocyclization Relay"],"prefix":"10.1021","volume":"28","author":[{"given":"Apurba","family":"Samanta","sequence":"first","affiliation":[{"name":"Indian Institute of Technology (ISM) Dhanbad , , , ,","place":["Dhanbad, Jharkhand, India, 826004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-8162","authenticated-orcid":true,"given":"Soumitra","family":"Maity","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (ISM) Dhanbad , , , ,","place":["Dhanbad, Jharkhand, India, 826004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"2026100208363780700_cit1a","doi-asserted-by":"publisher","first-page":"11721","DOI":"10.1039\/D2SC03948F","article-title":"Bicyclobutanes:\nfrom curiosities to versatile reagents and covalent warheads","volume":"13","author":"Kelly","year":"2022","journal-title":"Chem. sci."},{"key":"2026100208363780700_cit1b","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s42004-022-00811-3","article-title":"Bicyclobutanes as unusual building blocks for complexity\ngeneration in organic synthesis","volume":"6","author":"Golfmann","year":"2023","journal-title":"Commun. chem."},{"key":"2026100208363780700_cit1c","doi-asserted-by":"publisher","first-page":"20716","DOI":"10.1021\/jacs.3c08206","article-title":"Strain-release photocatalysis","volume":"145","author":"Bellotti","year":"2023","journal-title":"J. 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