{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:02:33Z","timestamp":1790787753618,"version":"4.1.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3805603"],"award-info":[{"award-number":["2022YFB3805603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009555","name":"Henan Normal University","doi-asserted-by":"publisher","award":["2024Y16"],"award-info":[{"award-number":["2024Y16"]}],"id":[{"id":"10.13039\/100009555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008256","name":"Nanjing Tech University","doi-asserted-by":"publisher","award":["39837137"],"award-info":[{"award-number":["39837137"]}],"id":[{"id":"10.13039\/501100008256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21801129"],"award-info":[{"award-number":["21801129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22078153"],"award-info":[{"award-number":["22078153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22378201"],"award-info":[{"award-number":["22378201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>1,3-Disubstituted bicyclo[1.1.1]pentanes (BCPs) represent privileged scaffolds in medicinal chemistry as pharmaceutical bioisosteres of benzene rings owing to their enhanced metabolic and pharmacokinetic properties. Herein, we demonstrate an unprecedented and practical photoredox-catalyzed direct C(sp2)-H trifluoromethyl-bicyclopentylation of enamides with bench-stable BCP-thianthrenium salt under environmentally friendly and transition-metal-free conditions, delivering a broad array of geometrically-defined E-configured enamides bearing the pharmaceutically prominent CF3-BCP entity in a regio- and stereoselective manner. The transformation proceeded through the Giese addition of structurally rigid CF3-BCP alkyl radical to electron-rich enamides and the ensuing oxidative radical\/polar crossover followed by \u03b2-H elimination. The synthetic utility of this methodology was further highlighted by its scalability and its capacity for streamlined late-stage functionalization, enabling access to various synthetically and biologically important organic intermediates and heterocycles.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03592","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:11:28Z","timestamp":1788531088000},"page":"11819-11824","source":"Crossref","is-referenced-by-count":1,"title":["Visible-Light-Induced\nRegio- and Stereoselective C(sp2)-H Trifluoromethyl-Bicyclopentylation\nof Enamides\nwith BCP-Thianthrenium Salt via Oxidative Radical\/Polar Crossover"],"prefix":"10.1021","volume":"28","author":[{"given":"Zeng","family":"Liu","sequence":"first","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hui","family":"Xing","sequence":"additional","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-5975","authenticated-orcid":true,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, P. R. China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-118X","authenticated-orcid":true,"given":"Zi","family":"Yang","sequence":"additional","affiliation":[{"name":"Changsha Medical University , , ,","place":["Changsha, P. R. China, 410219"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-806X","authenticated-orcid":true,"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nanjing Tech University , , ,","place":["Nanjing, P. R. China, 211816"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"2026091809431066800_cit1a","doi-asserted-by":"publisher","first-page":"6752","DOI":"10.1021\/jm901241e","article-title":"Escape from Flatland:\nIncreasing Saturation as an Approach to Improving Clinical Success","volume":"52","author":"Lovering","year":"2009","journal-title":"J. Med. 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Chem."},{"key":"2026091809431066800_cit2","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/cmdc.201700082","article-title":"Improving Nonspecific\nBinding and Solubility: Bicycloalkyl Groups and Cubanes as para-Phenyl Bioisosteres","volume":"12","author":"Auberson","year":"2017","journal-title":"ChemMedChem."},{"key":"2026091809431066800_cit3a","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature10108","article-title":"Catalysis\nfor Fluorination\nand Trifluoromethylation","volume":"473","author":"Furuya","year":"2011","journal-title":"Nature"},{"key":"2026091809431066800_cit3b","doi-asserted-by":"publisher","first-page":"6308","DOI":"10.1039\/D1CS00200G","article-title":"Radical Trifluoromethylation","volume":"50","author":"Xiao","year":"2021","journal-title":"Chem. Soc. 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