{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:02:54Z","timestamp":1790348574949,"version":"4.1.0"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013102","name":"Shanghai Municipal Youth Science and Technology Star Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0901900"],"award-info":[{"award-number":["2018YFA0901900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asperfuran is an antifungal natural product with a dihydrobenzofuran (DHB) nucleus. Herein, we identify a biosynthetic gene cluster responsible for its biosynthesis from Neosartorya pseudofischeri. Genetic and biochemical analysis revealed that the DHB nucleus of asperfuran is formed by a flavin-dependent monooxygenase-catalyzed ring contraction of a dihydroisocoumarin precursor, which is generated by a collaborative polyketide synthase assembly line with a C-terminal reductase domain. Our work unraveled a novel biosynthetic route to DHB synthesis.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03619","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:01:42Z","timestamp":1789228902000},"page":"12101-12105","source":"Crossref","is-referenced-by-count":0,"title":["Dihydrobenzofuran\nFormation through Ring Contraction\nof Dihydroisocoumarin Synthesized by a Polyketide Synthase Assembly\nLine with a Terminal Reductase Domain in Asperfuran Biosynthesis"],"prefix":"10.1021","volume":"28","author":[{"given":"Xiao-Xin","family":"Xue","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]},{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4604-7222","authenticated-orcid":true,"given":"Meng-Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]},{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]},{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-7545","authenticated-orcid":true,"given":"Xu-Dong","family":"Kong","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]},{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-3239","authenticated-orcid":true,"given":"Man-Cheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 200240"]},{"name":"Shanghai Jiao Tong University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"2026092510114519000_cit1a","doi-asserted-by":"publisher","first-page":"27510","DOI":"10.1039\/C9RA04917G","article-title":"Natural source, bioactivity and synthesis of benzofuran\nderivatives","volume":"9","author":"Miao","year":"2019","journal-title":"RSC Adv."},{"key":"2026092510114519000_cit1b","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1039\/c3np70014c","article-title":"Angular\ntricyclic benzofurans and related natural products of fungal origin.\nIsolation, biological activity and synthesis","volume":"30","author":"Simonetti","year":"2013","journal-title":"Nat. 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Gastroenterol."},{"key":"2026092510114519000_cit6a","doi-asserted-by":"publisher","first-page":"8247","DOI":"10.1021\/acs.orglett.6c01464","article-title":"Iron-Catalyzed Stereoselective Synthesis\nof Dihydrobenzofurans\nfrom O-Tethered Enynes and DDQ-Mediated Oxidative Annulation to Dibenzofurans","volume":"28","author":"Tripathi","year":"2026","journal-title":"Org. Lett."},{"key":"2026092510114519000_cit6b","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1021\/jacs.5c19165","article-title":"Construction of\nThree-Dimensional Covalent Organic Frameworks for Photocatalytic Synthesis\nof 2,3-Dihydrobenzofuran Derivatives","volume":"148","author":"Jin","year":"2026","journal-title":"J. Am.\nChem. 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