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Herein, we disclose a photoinduced radical epoxidation strategy that enables the direct construction of diverse fluorinated oxiranes from readily available fluoroalkyl halides and allylic peroxides without transition metals, photocatalysts, or external oxidants. This mild and oxidant-free protocol exhibits broad functional-group tolerance and accommodates a variety of bioactive molecules, natural-product derivatives, and pharmaceutical scaffolds, enabling the late-stage functionalization of complex molecules.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03640","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:01:39Z","timestamp":1791381699000},"page":"12922-12927","source":"Crossref","is-referenced-by-count":0,"title":["Metal- and Photosensitizer-Free\nRadical Strategy for\nthe Construction of Fluorinated Oxiranes"],"prefix":"10.1021","volume":"28","author":[{"given":"Shuaiqi","family":"Lu","sequence":"first","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjun","family":"He","sequence":"additional","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Duan","sequence":"additional","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Shen","sequence":"additional","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-2714","authenticated-orcid":true,"given":"Chao","family":"Shu","sequence":"additional","affiliation":[{"name":"Central China Normal University , , , ,","place":["Wuhan, Hubei, China, 430079"]},{"name":"Wuhan Institute of Photochemistry and Technology , 7 North Bingang Road , , ,","place":["Wuhan, Hubei, China, 430083"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026101608462352400_cit1","doi-asserted-by":"publisher","first-page":"107578","DOI":"10.1016\/j.cclet.2022.06.001","article-title":"Fluorine-containing\ndrugs approved by the FDA in 2021","volume":"34","author":"He","year":"2023","journal-title":"Chin. 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