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However, there is a lack of effective and simple methods for obtaining them. Herein, we have reported a copper- and photoredox-catalyzed multicomponent reaction for 1,3-enynes, NH4SCN, and NHPI esters, enabling the efficient synthesis of propargyl thiocyanates. SET and EDA strategies were applied. This novel method features redox-neutral conditions, wide substrate scope, and good functional group compatibility. The mechanistic experiment indicates that the reaction involves a radical process.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03663","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:02:22Z","timestamp":1791190942000},"page":"12916-12921","source":"Crossref","is-referenced-by-count":0,"title":["1,2-Alkylthiocyanation\nof 1,3-Enynes Enabled by Photoredox\nand Copper Catalysis"],"prefix":"10.1021","volume":"28","author":[{"given":"Wen-Chao","family":"Zhao","sequence":"first","affiliation":[{"name":"Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , , ,","place":["Hangzhou, China, 310024"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , , ,","place":["Hangzhou, China, 310024"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1848","authenticated-orcid":true,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , , ,","place":["Hangzhou, China, 310024"]},{"name":"Chinese Academy of Sciences , , ,","place":["Shanghai, China, 201203"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-6725","authenticated-orcid":true,"given":"Feng-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , , ,","place":["Hangzhou, China, 310024"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 101408"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026101608462637000_cit1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1021\/cr100359d","article-title":"Radical Cascades\nInitiated by Intermolecular Radical Addition to Alkynes and Related\nTriple Bond Systems","volume":"113","author":"Wille","year":"2013","journal-title":"Chem. 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Chem."},{"key":"2026101608462637000_cit19","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1002\/ejoc.202100367","article-title":"Propargyl Radicals\nin Organic Synthesis","volume":"2021","author":"Muresan","year":"2021","journal-title":"Eur. J. Org. Chem."},{"key":"2026101608462637000_cit20","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.1039\/D2SC02573F","article-title":"Radical transformations\nfor allene synthesis","volume":"13","author":"Li","year":"2022","journal-title":"Chem. Sci."},{"key":"2026101608462637000_cit21","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1039\/D2QO00994C","article-title":"Recent advances in\nthe metal-catalyzed asymmetric synthesis of chiral\nallenes","volume":"9","author":"Xiao","year":"2022","journal-title":"Org. Chem. 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Chem.\nFront."},{"key":"2026101608462637000_cit42","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202411469","article-title":"A General\nCopper-Box System for the Asymmetric Arylative Functionalization of\nBenzylic, Propargylic or Allenylic Radicals","volume":"63","author":"Wang","year":"2024","journal-title":"Angew. Chem., Int. 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