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The reaction exhibits excellent functional group tolerance and high efficiency, affording polycyclic products with significant biological activity. Mechanistic investigations, including control experiments and deuterium-labeling studies, were performed to elucidate the reaction pathway. Biological activity assays reveal that some compounds exhibit potent in vitro antiproliferative activity against PC-3 (prostate cancer) and HGC-27 (gastric cancer) cell lines.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03679","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:01:44Z","timestamp":1790578904000},"page":"12681-12686","source":"Crossref","is-referenced-by-count":0,"title":["Cascade Annulation of\n                    <i>o<\/i>\n                    -Alkynylbenzaldehydes\nwith Acrylamides: Access to Benzo[e]isoindolinone Scaffolds"],"prefix":"10.1021","volume":"28","author":[{"given":"Zhe","family":"Dong","sequence":"first","affiliation":[{"name":"Institute for Food Control, National Institutes for Food and Drug Control , ,","place":["Beijing, PR China, 102629"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhu","family":"Gao","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , , ,","place":["Zhengzhou, Henan, PR China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , , ,","place":["Zhengzhou, Henan, PR China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , , ,","place":["Zhengzhou, Henan, PR China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , , ,","place":["Zhengzhou, Henan, PR China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Su","sequence":"additional","affiliation":[{"name":"Henan University of Animal Husbandry and Economy , , ,","place":["Zhengzhou, PR China, 450046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-4503","authenticated-orcid":true,"given":"Congjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan University of Technology , , , ,","place":["Zhengzhou, Henan, PR China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026100910135201700_cit1a","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1021\/acs.jnatprod.2c00682","article-title":"Ulleungdolin, a\nPolyketide\u2013Peptide Hybrid Bearing\na 2,4-Di-O-methyl-\u03b2-d-antiarose from Streptomyces sp. 13F051\nCo-cultured with Leohumicola minima 15S071","volume":"85","author":"Hwang","year":"2022","journal-title":"J. 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