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Notably, hypercoretion A (1) represents a unique nor-PPAP characterized by a rearranged 5\/6\/6\/5 tetracyclic skeleton, while hypercoretion B (2) is the first example of a seco-nor-PPAP featuring an unusual 5\/5\/5 tricyclic skeleton. Their structures were established via spectroscopic analyses, X-ray diffraction, vibrational circular dichroism, and quantum chemical calculations. Biologically, the isolates were evaluated for their anti-liver fibrosis activities in TGF-\u03b21-stimulated LX-2 hepatic stellate cells.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03738","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:02:13Z","timestamp":1788940933000},"page":"11836-11842","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of\nDiverse Polycyclic Polyprenylated Acylphloroglucinols\nfrom\n                    <i>Hypericum kouytchense<\/i>\n                    with Anti-Liver\nFibrosis Potential"],"prefix":"10.1021","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7462-7688","authenticated-orcid":true,"given":"Zhaoyue","family":"Dong","sequence":"first","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. China, 400715"]},{"name":"Southwest University , , ,","place":["Yibin, P. R. China, 644000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdan","family":"Meng","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Wang","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Long","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. 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China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fancheng","family":"Meng","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-4192","authenticated-orcid":true,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. China, 400715"]},{"name":"Southwest University , , ,","place":["Yibin, P. R. 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