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However, the limited site selectivity of currently available sulfotransferases has made it challenging to access CS oligosaccharides with diverse sulfation patterns. Herein, we report a redox-controlled site-specific O-sulfation strategy for the programmable installation of CS-A, CS-C, or CS-E sequences at defined positions along chondroitin backbones, enabling the diversity-oriented synthesis of 28 structurally well-defined CS oligosaccharides with distinct sulfation sequences.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03858","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:02:31Z","timestamp":1791183751000},"page":"13052-13057","source":"Crossref","is-referenced-by-count":0,"title":["Redox-Controlled\nSite-Specific O-Sulfation\nFacilitated Diversity-Oriented Chemoenzymatic Synthesis of Chondroitin\nSulfates A\/C\/E and Chimeric Chondroitin Sulfates"],"prefix":"10.1021","volume":"28","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]},{"name":"Ocean University of China , , ,","place":["Sanya, China, 572025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Niu","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5128-0195","authenticated-orcid":true,"given":"Kan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Ye","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]},{"name":"The Scripps Research Institute , , , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Hu","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saddam M.","family":"Muthana","sequence":"additional","affiliation":[{"name":"Alfaisal University , , ,","place":["Riyadh, Kingdom of Saudi Arabia, 11533"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-3143","authenticated-orcid":true,"given":"Hongzhi","family":"Cao","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]},{"name":"Ocean University of China , , ,","place":["Sanya, China, 572025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026101608465264500_cit1a","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126551","article-title":"Advances and\nChallenges in Biotechnological Production of Chondroitin Sulfate and\nIts Oligosaccharides","volume":"253","author":"Zhang","year":"2023","journal-title":"Int. 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