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Mechanistic investigations indicate that the silyl substituent functions as a directing element for regioselectivity control. DFT calculations further reveal that the allyl addition is the regio-determining step, where the branched allylcopper species shows a markedly lower activation barrier. The vinylsilane products serve as versatile platforms for downstream functionalization, enabling efficient carbon-chain elongation.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c03882","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:01:49Z","timestamp":1791374509000},"page":"13023-13028","source":"Crossref","is-referenced-by-count":0,"title":["Harnessing the\nSilicon Effect for Copper-Catalyzed\nLinear-\n                    <i>E<\/i>\n                    -Selective Reductive Coupling\nof Ketones with Allenylsilanes"],"prefix":"10.1021","volume":"28","author":[{"given":"Qingbin","family":"Lu","sequence":"first","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiang","family":"Ye","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Li","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihui","family":"Gong","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyi","family":"Li","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Lin","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Gao","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. R. China, 210009"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026101608471157800_cit1","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1021\/acs.jnatprod.8b01022","article-title":"A systematic cheminformatics analysis of functional\ngroups occurring in natural products","volume":"82","author":"Ertl","year":"2019","journal-title":"J. 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