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A streamlined route employing methoxylative bromination and dual catalytic XAT-mediated elimination enabled access to pseudo-herpotrichone C. SAR studies revealed that C4\u2013C19 stereochemistry, C16\u2013C18 arrangement, and C3 substitution of the herpotrichone framework collectively govern the neuroprotective activity. Notably, synthetic derivatives 4 and 5 inhibited LPS-induced nitric oxide production more strongly than natural herpotrichones A and B.<\/jats:p>","DOI":"10.1021\/acs.orglett.6c04044","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:01:37Z","timestamp":1791223297000},"page":"13104-13109","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of\n                    <i>Pseudo<\/i>\n                    -herpotrichone\nC and Structure\u2013Activity Relationship Study of Herpotrichone-Based\nInhibitors against Neuroinflammation"],"prefix":"10.1021","volume":"28","author":[{"given":"Yoojin","family":"Lee","sequence":"first","affiliation":[{"name":"Korea Advanced Institute of Science & Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]},{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taejin","family":"Chu","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology (KIST) , , ,","place":["Seoul, Republic of Korea, 02792"]},{"name":"University of Science and Technology , , ,","place":["Seoul, Republic of Korea, 02792"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology (KIST) , , ,","place":["Seoul, Republic of Korea, 02792"]},{"name":"University of Science and Technology , , ,","place":["Seoul, Republic of Korea, 02792"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-6794","authenticated-orcid":true,"given":"Sunkyu","family":"Han","sequence":"additional","affiliation":[{"name":"Korea Advanced Institute of Science & Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]},{"name":"Korea Advanced Institute of Science and Technology (KAIST) , , ,","place":["Daejeon, Republic of Korea, 34141"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"6","key":"2026101608470059200_cit1","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1021\/cr980013j","article-title":"Naturally Occurring Cyclohexane Epoxides:\nSources, Biological Activities, and Synthesis","volume":"104","author":"Marco-Contelles","year":"2004","journal-title":"Chem. 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