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A hydrogen-mediated reductive coupling of acetylene with a Roche-type aldehyde is used to construct C(7)\u2013C(13). A 2-propanol-mediated reductive coupling of allyl acetate with (E)-2-methylbut-2-enal at a low loading of iridium (1 mol %) is used to construct C(1)\u2013C(6), which is converted to an allylsilane using Oestereich\u2019s copper-catalyzed allylic substitution of Si\u2013Zn reagents. The union of the C(1)\u2013C(6) and C(7)\u2013C(13) fragments is achieved via stereoselective Sakurai allylation.<\/jats:p>","DOI":"10.1021\/acs.orglett.7b03351","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T08:00:25Z","timestamp":1511424025000},"page":"6634-6637","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis of the C(1)\u2013C(13) Fragment of Leiodermatolide\nvia Hydrogen-Mediated C\u2013C Bond Formation"],"prefix":"10.1021","volume":"19","author":[{"given":"James","family":"Roane","sequence":"first","affiliation":[{"name":"University of Texas at Austin , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Wippich","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Ramgren","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-9709","authenticated-orcid":true,"given":"Michael J.","family":"Krische","sequence":"additional","affiliation":[{"name":"University of Texas at Austin , , ,","place":["Austin, Texas, United States, 78712"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"2026090309154586200_cit1a","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nrc1317","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. 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