{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:26:59Z","timestamp":1790886419960,"version":"4.1.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["413\/22"],"award-info":[{"award-number":["413\/22"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021131","name":"Azrieli College of Engineering Jerusalem","doi-asserted-by":"publisher","award":["SM2022-2023"],"award-info":[{"award-number":["SM2022-2023"]}],"id":[{"id":"10.13039\/100021131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology, Israel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Israeli Ministry of Innovation, Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Bio Mater."],"published-print":{"date-parts":[[2024,3,18]]},"DOI":"10.1021\/acsabm.3c01133","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T22:13:05Z","timestamp":1707516785000},"page":"1682-1693","source":"Crossref","is-referenced-by-count":29,"title":["Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery"],"prefix":"10.1021","volume":"7","author":[{"given":"Hala","family":"Dawud","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, Azrieli College of Engineering Jerusalem, Jerusalem 9103501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Edelstein-Pardo","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"The Center for Physics and Chemistry of Living Systems, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"The Center for Nanoscience and Nanotechnology, Tel-Aviv University, Tel-Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthana","family":"Mulamukkil","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"The Center for Physics and Chemistry of Living Systems, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"The Center for Nanoscience and Nanotechnology, Tel-Aviv University, Tel-Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-3302","authenticated-orcid":true,"given":"Roey J.","family":"Amir","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"The Center for Physics and Chemistry of Living Systems, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"The Center for Nanoscience and Nanotechnology, Tel-Aviv University, Tel-Aviv 6997801, Israel"},{"name":"ADAMA Center for Novel Delivery Systems in Crop Protection, Tel-Aviv University, Tel-Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-3120","authenticated-orcid":true,"given":"Aiman","family":"Abu Ammar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Azrieli College of Engineering Jerusalem, Jerusalem 9103501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.2c03003"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3776"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1742324"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/mi12111321"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.048"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060569"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/B978-0-12-802926-8.00007-0","volume-title":"Nanoscience in Dermatology","author":"Manikkath J.","year":"2016"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-12-802926-8.00005-7","volume-title":"Nanoscience in Dermatology","author":"Wang M.","year":"2016"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119673"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000307"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119580"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.12.003"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.07.009"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121612"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.03.011"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2020.0496"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130561"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2021.03.012"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051407"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja413036q"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10624"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01708"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.2c00859"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","unstructured":"Rathee, P.; Edelstein-Pardo, N.; Sitt, A.; Amir, R. J. Polymeric Architecture as a Tool for Programming Sequential Enzyme-Induced Mesophase Transitions; preprint; Chemistry, 2022. 10.26434\/chemrxiv-2022-20ntd.","DOI":"10.26434\/chemrxiv-2022-20ntd"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13080934"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020526"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.05.042"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01143C"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101601"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.12.023"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1081\/JLC-200025726"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acspolymersau.2c00023"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2860(02)00642-7"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b02318"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111547"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/gels9100806"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.161"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/coatings13020425"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-8686(99)00037-8"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/B978-0-12-802447-8.00007-8","volume-title":"Developing Solid Oral Dosage Forms","author":"Brady J.","year":"2017"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.12.027"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120578"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030454"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01526"},{"key":"ref45\/cit45","volume-title":"Pharmaceutical Formulation Design - Recent Practices","author":"Yohana Chaerunisaa A.","year":"2020"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0276-7"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.02.009"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121928"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2015.11.029"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.10.049"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2023.05.009"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.05.143"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01426-5"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2016.06.006"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2182"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-0028-9"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104384"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/pen.760220402"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/0144-8617(90)90067-3"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-4748-4","volume-title":"Structure\u2500Property Relationships in Polymers","author":"Seymour R. B.","year":"1984"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2013.07.009"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.01.005"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00112-0"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(87)90034-4"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1517\/17425241003602259"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.3c00153"},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-12-822550-9.00009-0","volume-title":"Transdermal Drug Delivery","author":"Ita K.","year":"2020"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.07.010"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.07.012"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s00542-009-0883-5"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA04340A"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c02330"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3390\/mi12020117"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2017.12.006"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120475"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-019-0449-y"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.3c01133","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.3c01133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:11:37Z","timestamp":1710749497000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsabm.3c01133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,18]]}},"alternative-id":["10.1021\/acsabm.3c01133"],"URL":"https:\/\/doi.org\/10.1021\/acsabm.3c01133","relation":{},"ISSN":["2576-6422","2576-6422"],"issn-type":[{"value":"2576-6422","type":"print"},{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]}}}