{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:54:23Z","timestamp":1786676063488,"version":"build-2736575974"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["IF200192"],"award-info":[{"award-number":["IF200192"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Bio Mater."],"published-print":{"date-parts":[[2025,7,21]]},"DOI":"10.1021\/acsabm.5c00567","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T02:47:13Z","timestamp":1750042033000},"page":"5883-5902","source":"Crossref","is-referenced-by-count":10,"title":["Nanotechnology-Driven Colorectal Cancer Treatment: Coencapsulation of Irinotecan and Cyclosporine A in SNEDDS for Superior Outcomes"],"prefix":"10.1021","volume":"8","author":[{"given":"Rati","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padakanti Sandeep","family":"Chary","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshada","family":"Bhalerao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhavi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Pardhi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Sonti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-8065","authenticated-orcid":true,"given":"Neelesh Kumar","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics","place":["Hyderabad, India"]},{"name":"National Institute of Pharmaceutical Education and Research","place":["Hyderabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-024-01791-5"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.10.022"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-024-02759-0"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-024-02928-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1616237"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2009.07.010"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.02.065"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144919"},{"key":"ref10\/cit10","unstructured":"CAMPTOSAR Pfizer. https:\/\/www.pfizer.com\/products\/product-detail\/camptosar (accessed May 01, 2025)."},{"key":"ref11\/cit11","unstructured":"Irinotecan Pathway,\nPharmacokinetics. https:\/\/www.pharmgkb.org\/pathway\/PA2001 (accessed May 02, 2025)."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.7.763"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/s0928-0987(00)00167-6"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2011.561784"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/life12060897"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108488"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104161"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s002280100315"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2174\/138920011798357006"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.02.002"},{"issue":"11","key":"ref21\/cit21","first-page":"2964","volume":"60","author":"Newman M. J.","year":"2000","journal-title":"Cancer Res."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01634-6"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.10.010"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124473"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105493"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2004.02.001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124109"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.10.020"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102320"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2012.01.032"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2019.111098"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103117"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2023.2289133"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/17435889.2024.2390348"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.275"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2024.2391225"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00377-9"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-023-01462-0"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7765"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.127225"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4984"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s44303-023-00001-3"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-023-00368-3"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102204"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030853"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA27096D"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.126"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c08700"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s95905"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73760-7"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101783"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","unstructured":"Frizzo, C. P.; Tier, A. Z.; Bender, C. R.; Gindri, I. M.; Villetti, M. A.; Zanatta, N.; Bonacorso, H. G.; Martins, M. A. P. Structural and Physical Aspects of Ionic Liquid Aggregates in Solution; IntechOpen, 2015; pp 1\u201327.","DOI":"10.5772\/59287"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.03.008"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/molecules201219745"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2016.02.081"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2011.09.048"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.09.003"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-021-00312-5"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.5c00567","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.5c00567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:12:39Z","timestamp":1753085559000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsabm.5c00567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,21]]}},"alternative-id":["10.1021\/acsabm.5c00567"],"URL":"https:\/\/doi.org\/10.1021\/acsabm.5c00567","relation":{},"ISSN":["2576-6422","2576-6422"],"issn-type":[{"value":"2576-6422","type":"print"},{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]}}}