{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:58:53Z","timestamp":1785351533691,"version":"3.55.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In normal synovial membranes, CD68-fibroblast-like synoviocytes (FLSs) and CD68+ macrophage-like synoviocytes (MLSs) form a bilayer structure and secrete heteroglycans and proteins (primarily hyaluronic acid [HA] and lubricin [PRG4]) that lubricate the joint and produce synovial fluid. Notably, despite the important role of synovial membrane cells in rheumatological diseases, such as osteoarthritis (OA) and rheumatoid arthritis (RA), relatively few artificial synovial membrane models exist in the literature, and those that have been presented are often minimally biomimetic. HA is an integral part of a healthy synovial membrane and synovial fluid. Utilization of strategies introducing HA has been studied earlier; however, no such study exists utilizing endogenous HA for tissue engineering of the synovial membrane. In this study, we utilized hyaluronic acid binding peptide (HABPs) functionalized onto nanofibrous poly-\u03b5-caprolactone (PCL) scaffolds following electrospinning. The physical properties, such as surface morphology and surface tribology, of these scaffolds were tested to ensure they exhibit characteristics reminiscent of the native synovial membranes. To further mimic the native synovial membranes, human dermal fibroblasts (hDFs) were seeded onto the surfaces of the HABP-functionalized scaffolds. In the study, the development of cells and their production of HA were tested to evaluate the therapeutic effect of artificial synovial membranes. The results showed that HABP-functionalized scaffolds aid in cell proliferation, HA retention on scaffolds, and HA secretion into the cell culture supernatant by hDFs. We conclude that HABP-functionalized artificial synovial membranes cultured with fibroblasts can serve as a suitable scaffold toward tissue engineering of human synovial membranes.<\/jats:p>","DOI":"10.1021\/acsabm.5c01205","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:40:33Z","timestamp":1759779633000},"page":"9854-9863","source":"Crossref","is-referenced-by-count":1,"title":["Developing an Artificial\nSynovial Membrane Model Using\nHyaluronic Acid-Binding Peptides"],"prefix":"10.1021","volume":"8","author":[{"given":"Mingyang","family":"Mao","sequence":"first","affiliation":[{"name":"South Dakota School of Mines and Technology , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-2971","authenticated-orcid":true,"given":"Forest","family":"Thompson","sequence":"additional","affiliation":[{"name":"South Dakota School of Mines , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Ballard","sequence":"additional","affiliation":[{"name":"South Dakota School of Mines and Technology , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosein","family":"Mirazi","sequence":"additional","affiliation":[{"name":"South Dakota School of Mines and Technology , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Terkildsen","sequence":"additional","affiliation":[{"name":"South Dakota School of Mines and Technology and Technology , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Shchepin","sequence":"additional","affiliation":[{"name":"South Dakota School of Mines and Technology and Technology , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-0547","authenticated-orcid":true,"given":"Scott","family":"Wood","sequence":"additional","affiliation":[{"name":"University of New England , , , ,","place":["Biddeford, Maine, United States, 04005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3800-0463","authenticated-orcid":true,"given":"Tugba","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"South Dakota School of Mines and Technology , , , ,","place":["Rapid City, South Dakota, United States, 57701"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"4","key":"2026072914073555600_cit1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/art.1780100407","article-title":"Hyaluronic acid in\nsynovial fluid. I. Molecular parameters of hyaluronic acid in normal\nand arthritic human fluids","volume":"10","author":"Balazs","year":"1967","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2026072914073555600_cit2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40824-018-0118-x","article-title":"Regulation\nof lubricin for functional\ncartilage tissue regeneration: a review","volume":"22","author":"Lee","year":"2018","journal-title":"Biomater.\nRes."},{"issue":"1","key":"2026072914073555600_cit3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2174\/1874312901105010100","article-title":"The normal\nsynovium","volume":"5","author":"Smith","year":"2011","journal-title":"Open Rheumatol. 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Immunol."},{"issue":"3","key":"2026072914073555600_cit5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1136\/ard.30.3.322","article-title":"Lubrication\nof synovial membrane","volume":"30","author":"Radin","year":"1971","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"2026072914073555600_cit6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/ard.33.4.318","article-title":"Role of hyaluronic acid in joint lubrication","volume":"33","author":"Swann","year":"1974","journal-title":"Ann Rheum Dis"},{"issue":"2\u20133","key":"2026072914073555600_cit7","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1113\/jphysiol.1953.sp004842","article-title":"The physiological function\nof hyaluronic acid in synovial\nfluid; viscous, elastic and lubricant properties","volume":"119","author":"Ogston","year":"1953","journal-title":"J Physiol"},{"issue":"7\u20138","key":"2026072914073555600_cit8","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1089\/ten.tea.2018.0142","article-title":"A functional tissue-engineered\nsynovium model to study\nosteoarthritis progression and treatment","volume":"25","author":"Stefani","year":"2019","journal-title":"Tissue\nEng. 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Ed."},{"issue":"25","key":"2026072914073555600_cit32","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1016\/j.biomaterials.2009.04.015","article-title":"The interaction\nbetween bone marrow\nstromal cells and RGD-modified three-dimensional porous polycaprolactone\nscaffolds","volume":"30","author":"Zhang","year":"2009","journal-title":"Biomaterials"},{"key":"2026072914073555600_cit33","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.biomaterials.2018.08.045","article-title":"A hyaluronic acid binding peptide-polymer\nsystem for treating osteoarthritis","volume":"183","author":"Faust","year":"2018","journal-title":"Biomaterials"},{"issue":"8","key":"2026072914073555600_cit34","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3390\/biomimetics9080499","article-title":"Biomimetic Hyaluronan Binding Biomaterials\nto Capture the Complex Regulation of Hyaluronan in Tissue Development\nand Function","volume":"9","author":"Huffer","year":"2024","journal-title":"Biomimetics"},{"key":"2026072914073555600_cit35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000544881","article-title":"Hyaluronic\nAcid Binding Peptide Regulates Extracellular Matrix Deposition and\nDiminishes Fibroblast Contractility","author":"Blake","year":"2025","journal-title":"Cells Tissues\nOrgans"},{"issue":"1","key":"2026072914073555600_cit36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.22203\/eCM.v013a03","article-title":"A model of synovial fluid lubricant composition in normal and injured\njoints","volume":"13","author":"Blewis","year":"2007","journal-title":"Eur. 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