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To address this, we developed a functional injectable sodium alginate\/bioactive glass (SA\/BG) hydrogel loaded with a juxtamembrane-2 (JM2) mimic peptide (JM2@SA\/BG) for breast tumor postsurgical treatment. The hydrogel exhibited rapid in situ gelation, tunable swelling, and mechanical strength well-matched to natural breast tissue, with JM2 incorporation increasing crosslinking density through ionic and hydrogen bonding. A sustained, diffusion-controlled release of JM2 was achieved by encapsulating JM2 into the SA\/BG hydrogel, which was consistent with the Higuchi model, ensuring prolonged therapeutic bioavailability. In vitro, JM2 exhibited a selective inhibition on 4T1 breast cancer cells (IC50 = 65 \u03bcg\/mL) while maintaining high biocompatibility with fibroblasts. In vivo, with a murine breast cancer postsurgery model, the JM2@SA\/BG hydrogel significantly suppressed tumor recurrence, evidenced by the reduced Ki67-positive proliferating cells, increased TUNEL-positive apoptotic cells, and nuclear abnormalities in the remaining tumor tissue demonstrated by H&amp;E staining. Collectively, these results highlight the JM2@SA\/BG hydrogel as a promising injectable and functional platform that provides spatiotemporal control of drug delivery, possesses localized anticancer activity, and offers an effective strategy to suppress tumor recurrence in breast cancer postsurgery therapy.<\/jats:p>","DOI":"10.1021\/acsabm.5c02571","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:51:22Z","timestamp":1785131482000},"page":"7243-7256","source":"Crossref","is-referenced-by-count":0,"title":["Juxtamembrane Mimic Peptide Loaded Injectable Sodium Alginate\/Bioglass Bioactive Hydrogel for Suppressing Tumor Recurrence in Post-Breast-Conserving-Surgery Treatment"],"prefix":"10.1021","volume":"9","author":[{"given":"Yiping","family":"Fan","sequence":"first","affiliation":[{"name":"RMIT University , , , ,","place":["Melbourne, Victoria, Australia, 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