{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:25:07Z","timestamp":1790083507792,"version":"4.0.1"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200302"],"award-info":[{"award-number":["82200302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Entrepreneurship Subsidy for Overseas Professionals","award":["2024007"],"award-info":[{"award-number":["2024007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Bio Mater."],"published-print":{"date-parts":[[2026,5,18]]},"DOI":"10.1021\/acsabm.6c00032","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:24:35Z","timestamp":1777890275000},"page":"4465-4476","source":"Crossref","is-referenced-by-count":1,"title":["Piperazine-Derived Diamine Lipid Nanoparticles Targeting to the Liver for Delivering Clustered Regularly Interspaced Short Palindromic Repeat Editing of PCSK9 to Durably Maintain Plasmatic Low-Density Lipoprotein Cholesterol in Low Levels"],"prefix":"10.1021","volume":"9","author":[{"given":"Shifeng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery","place":["Beijing, China"]},{"name":"Beijing Anzhen Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-8077","authenticated-orcid":true,"given":"Shiyun","family":"Huang","sequence":"additional","affiliation":[{"name":"Edibeck Therapeutics","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering","place":["Hangzhou, PR China"]},{"name":"Zhejiang University","place":["Hangzhou, PR China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["Hangzhou, PR China"]},{"name":"The Second Affiliated Hospital, School of Medicine, Zhejiang University","place":["Hangzhou, PR China"]},{"name":"Transvascular Implantation Devices Research Institute China","place":["Hangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neng","family":"Wang","sequence":"additional","affiliation":[{"name":"Edibeck Therapeutics","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Yu","sequence":"additional","affiliation":[{"name":"Edibeck Therapeutics","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Edibeck Therapeutics","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1415-4287","authenticated-orcid":true,"given":"Zhenhuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Edibeck Therapeutics","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery","place":["Beijing, China"]},{"name":"Beijing Anzhen Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03534-y"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020459"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304351"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3632"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa247"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.02.020"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0153-2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.054"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.02.019"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.02.047"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.04.100"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/ng1161"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12389"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2022.08.015"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609243"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320902750"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03508-x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4005"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02437-3"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300502"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903618"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.280"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.02.016"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.03.043"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209624"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12893"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-023-01030-4"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.100766"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103479"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32281-5"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b02664"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00544"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062132"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107454"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00032","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:10:28Z","timestamp":1779091828000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsabm.6c00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5,18]]}},"alternative-id":["10.1021\/acsabm.6c00032"],"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00032","relation":{},"ISSN":["2576-6422","2576-6422"],"issn-type":[{"value":"2576-6422","type":"print"},{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]}}}