{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:52:08Z","timestamp":1785761528406,"version":"3.56.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20250484959"],"award-info":[{"award-number":["20250484959"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJZD-K202301503"],"award-info":[{"award-number":["KJZD-K202301503"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015019","name":"Chongqing University of Science and Technology","doi-asserted-by":"publisher","award":["YKJCX2520301"],"award-info":[{"award-number":["YKJCX2520301"]}],"id":[{"id":"10.13039\/501100015019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Conventional gelatin (Gel) and alginate hydrogels possess excellent biocompatibility. Their high water content and three-dimensional porous structure mimic the extracellular matrix, facilitating nutrient transport and metabolic waste removal. However, their application in bone tissue engineering is hindered by insufficient mechanical strength, rapid degradation, and weak osteogenic activity. In this study, we developed a self-cross-linking hydrogel (GOP hydrogel) reinforced with calcium phosphate oligomers (CPO). The network was formed via a Schiff base reaction between periodate-oxidized sodium alginate (OSA) and gelatin, with small-sized CPO acting as an inorganic cross-linker to enhance intermolecular bonding and strengthen the polymeric network. The composite hydrogel was characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), and its mechanical properties, degradation behavior, and swelling capacity were evaluated. The GOP hydrogel exhibited excellent biocompatibility, supported cell viability and osteogenic differentiation, and promoted vascularized healing in critical-sized calvarial defects in rats. With the incorporation of CPO, the hydrogels exhibited enhanced mechanical strength, regulated degradation and swelling, and improved mineralization and osteogenic activity. These findings indicate that the GOP hydrogel meets the key requirements for bone tissue engineering scaffolds and holds considerable promise for bone regeneration applications.<\/jats:p>","DOI":"10.1021\/acsabm.6c00104","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:39:56Z","timestamp":1783967996000},"page":"6887-6900","source":"Crossref","is-referenced-by-count":0,"title":["A Biomimetic Nanocomposite Hydrogel Cross-Linked by Calcium Phosphate Oligomers for Bone Regeneration"],"prefix":"10.1021","volume":"9","author":[{"given":"Lingfei","family":"Liu","sequence":"first","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University School and Hospital of Stomatology; National Center of Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues; and Beijing Key Laboratory of Biomaterials for Oral Disease , , ,","place":["Beijing, China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyan","family":"Xia","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsi","family":"Yu","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihang","family":"Sun","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yan","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-0844","authenticated-orcid":true,"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongning","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University School and Hospital of Stomatology; National Center of Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices; Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues; and Beijing Key Laboratory of Biomaterials for Oral Disease , , ,","place":["Beijing, China, 100081"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"41","key":"2026080308065044900_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202403235","article-title":"Continuous Manufacturing of Bioinspired Bone-Periosteum Integrated Scaffold to Promote Bone Regeneration","volume":"34","author":"Li","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"2026080308065044900_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110430","article-title":"Biodegradable magnesium incorporated microspheres enable immunomodulation and spatiotemporal drug release for the treatment of osteonecrosis of the femoral head","volume":"250","author":"Yang","year":"2023","journal-title":"Composites, Part B"},{"issue":"31","key":"2026080308065044900_cit3","doi-asserted-by":"publisher","first-page":"13614","DOI":"10.1073\/pnas.1003600107","article-title":"Osteoinductive ceramics as a synthetic alternative to autologous bone grafting","volume":"107","author":"Yuan","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"2026080308065044900_cit4","doi-asserted-by":"publisher","first-page":"6840","DOI":"10.1021\/acsnano.4c11960","article-title":"Micro\/Nanobiomimetic Iron-Based Scaffold Induces Vascularized Bone Regeneration To Repair Large Segmental Bone Defect in Load-Bearing Sites","volume":"19","author":"Yuan","year":"2025","journal-title":"ACS Nano"},{"issue":"34","key":"2026080308065044900_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502598","article-title":"Homogeneous \"Hard-Soft\" Biphasic Bone Adhesives Promote Comminuted Fracture Healing through Interfacial Adaptation and Mechanical Property Maintenance","volume":"37","author":"Zhou","year":"2025","journal-title":"Adv. Mater."},{"issue":"3","key":"2026080308065044900_cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201349","article-title":"Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair","volume":"12","author":"Jing","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"2026080308065044900_cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.138323","article-title":"A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications","volume":"287","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026080308065044900_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119458","article-title":"Simultaneous nano- and microscale structural control of injectable hydrogels via the assembly of nanofibrous protein microparticles for tissue regeneration","volume":"223","author":"Hou","year":"2019","journal-title":"Biomaterials"},{"issue":"44","key":"2026080308065044900_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202204974","article-title":"A Novel Hollow-Tube-Biphasic-Whisker-Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity","volume":"32","author":"Feng","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"18","key":"2026080308065044900_cit10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26189066","article-title":"Functional Hydrogels: A Promising Platform for Biomedical and Environmental Applications","volume":"26","author":"Quazi","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026080308065044900_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122601","article-title":"Structure driven bio-responsive ability of injectable nanocomposite hydrogels for efficient bone regeneration","volume":"309","author":"Song","year":"2024","journal-title":"Biomaterials"},{"issue":"11","key":"2026080308065044900_cit12","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1021\/cr800427g","article-title":"Calcium phosphate-based osteoinductive materials","volume":"108","author":"LeGeros","year":"2008","journal-title":"Chem. Rev."},{"key":"2026080308065044900_cit13","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.bioactmat.2021.10.006","article-title":"Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size","volume":"11","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"issue":"1","key":"2026080308065044900_cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30243-5","article-title":"An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis","volume":"13","author":"Lu","year":"2022","journal-title":"Nat. Commun."},{"issue":"5","key":"2026080308065044900_cit15","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1002\/anie.201913828","article-title":"Organic-Inorganic Copolymerization for a Homogenous Composite without an Interphase Boundary","volume":"59","author":"Yu","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026080308065044900_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2024.105951","article-title":"Self-healing hydrogel prepared from gallic acid coupled P(NIPAM-co-AH) and oxidized sodium alginate for diabetic wound repairing","volume":"201","author":"Sun","year":"2024","journal-title":"React. Funct. Polym."},{"key":"2026080308065044900_cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118937","article-title":"Bioremediation of 2,4,6-trichlorophenol by extracellular enzymes of white rot fungi immobilized with sodium alginate\/hydroxyapatite\/chitosan microspheres","volume":"252","author":"Wu","year":"2024","journal-title":"Environ. Res."},{"key":"2026080308065044900_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.112823","article-title":"Tri-network, physical cross-linked sodium alginate hydrogel with strongly self-healing capacity and highly tough, for wearable flexible devices","volume":"209","author":"Li","year":"2024","journal-title":"Eur. Polym. J."},{"key":"2026080308065044900_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121812","article-title":"Tough, self-healing and injectable dynamic nanocomposite hydrogel based on gelatin and sodium alginate","volume":"330","author":"Gao","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"17","key":"2026080308065044900_cit20","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1016\/s0142-9612(00)00072-7","article-title":"Alginates from wound dressings activate human macrophages to secrete tumour necrosis factor-\u03b1","volume":"21","author":"Thomas","year":"2000","journal-title":"Biomaterials"},{"issue":"4","key":"2026080308065044900_cit21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1524-475X.2009.00496.x","article-title":"The biological effects of topical alginate treatment in an animal model of skin wound healing","volume":"17","author":"Lee","year":"2009","journal-title":"Wound Repair Regen."},{"issue":"1","key":"2026080308065044900_cit22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","article-title":"Alginate: Properties and biomedical applications","volume":"37","author":"Lee","year":"2012","journal-title":"Prog. Polym. Sci."},{"issue":"3","key":"2026080308065044900_cit23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.carbpol.2006.05.025","article-title":"Oxidation of sodium alginate and characterization of the oxidized derivatives","volume":"67","author":"Gomez","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"2026080308065044900_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129996","article-title":"Self-healable oxide sodium alginate\/carboxymethyl chitosan nanocomposite hydrogel loading Cu2+-doped MOF for enhanced synergistic and precise cancer therapy","volume":"262","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"2026080308065044900_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201822","article-title":"Partially Oxidized Alginate as a Biodegradable Carrier for Glucose-Responsive Insulin Delivery and Islet Cell Replacement Therapy","volume":"12","author":"Volpatti","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"19","key":"2026080308065044900_cit26","doi-asserted-by":"publisher","first-page":"10386","DOI":"10.1021\/acsami.5b01433","article-title":"Photo-cross-linkable methacrylated gelatin and hydroxyapatite hybrid hydrogel for modularly engineering biomimetic osteon","volume":"7","author":"Zuo","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026080308065044900_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130380","article-title":"Silk fibroin\/methacrylated gelatine\/hydroxyapatite biomimetic nanofibrous membranes for guided bone regeneration","volume":"263","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026080308065044900_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123480","article-title":"Synthesis of oxidized sodium alginate and its electrospun bio-hybrids with zinc oxide nanoparticles to promote wound healing","volume":"232","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"15","key":"2026080308065044900_cit29","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How useful is SBF in predicting in vivo bone bioactivity?","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"},{"issue":"4","key":"2026080308065044900_cit30","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/jbm.b.33070","article-title":"Terminal sterilization of alginate hydrogels: Efficacy and impact on mechanical properties","volume":"102","author":"Stoppel","year":"2014","journal-title":"J. Biomed. Mater. Res., Part B"},{"key":"2026080308065044900_cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2022.132784","article-title":"Preparation of an artificial crystal skull and its formation mechanism","volume":"325","author":"Shu","year":"2022","journal-title":"Mater. Lett."},{"issue":"31","key":"2026080308065044900_cit32","doi-asserted-by":"publisher","first-page":"11739","DOI":"10.1021\/acssuschemeng.4c03668","article-title":"Self-Cross-Linked Oxidized Sodium Alginate\/Gelatin\/Halloysite Hydrogel as Injectable, Adhesive, Antibacterial Dressing for Hemostasis","volume":"12","author":"Lin","year":"2024","journal-title":"ACS Sustainable Chem. Eng."},{"key":"2026080308065044900_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131905","article-title":"Fermentation-inspired macroporous and tough gelatin\/sodium alginate hydrogel for accelerated infected wound healing","volume":"268","author":"Cheng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"15","key":"2026080308065044900_cit34","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/polym14153199","article-title":"Characterization and Application in Packaging Grease of Gelatin-Sodium Alginate Edible Films Cross-Linked by Pullulan","volume":"14","author":"Li","year":"2022","journal-title":"Polymers"},{"issue":"7969","key":"2026080308065044900_cit35","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41586-023-06117-1","article-title":"Organic\u2212inorganic covalent\u2212ionic molecules for elastic ceramic plastic","volume":"619","author":"Fang","year":"2023","journal-title":"Nature"},{"issue":"1","key":"2026080308065044900_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202000517","article-title":"Micelle Crosslinked Polyacrylic Acid Hydrogels with Resilience and Self-Recovery Properties","volume":"306","author":"Gulyuz","year":"2021","journal-title":"Macromol. Mater. Eng."},{"key":"2026080308065044900_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119335","article-title":"Chitosan and carboxymethyl chitosan mimic biomineralization and promote microbially induced calcium precipitation","volume":"287","author":"Wang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"2026080308065044900_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.104682","article-title":"Biomimetic mineralization of poly(L-lactic acid) nanofibrous microspheres for bone regeneration","volume":"33","author":"Li","year":"2022","journal-title":"Mater. Today Commun."},{"issue":"12","key":"2026080308065044900_cit39","doi-asserted-by":"publisher","first-page":"6737","DOI":"10.1021\/acsbiomaterials.0c00972","article-title":"Biomimetic Membranes of Methacrylated Gelatin\/Nanohydroxyapatite\/Poly(L-Lactic Acid) for Enhanced Bone Regeneration","volume":"6","author":"Li","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"8","key":"2026080308065044900_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax6946","article-title":"Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect","volume":"5","author":"Zhang","year":"2019","journal-title":"Sci. Adv."},{"issue":"3","key":"2026080308065044900_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202309042","article-title":"Bionic Mineralized 3D-Printed Scaffolds with Enhanced In Situ Mineralization for Cranial Bone Regeneration","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"2026080308065044900_cit42","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1021\/acsami.2c16217","article-title":"In Situ Biomimetic Mineralization of Bone-Like Hydroxyapatite in Hydrogel for the Acceleration of Bone Regeneration","volume":"15","author":"Liang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"2026080308065044900_cit43","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/adf386","article-title":"The enhanced osteogenesis of calcium phosphate oligomers modified collagen membrane to guide bone regeneration","volume":"20","author":"Xu","year":"2025","journal-title":"Biomed. Mater."},{"issue":"27","key":"2026080308065044900_cit44","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1016\/j.biomaterials.2009.05.022","article-title":"Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering","volume":"30","author":"Osathanon","year":"2009","journal-title":"Biomaterials"},{"issue":"50","key":"2026080308065044900_cit45","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4704","article-title":"A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair","volume":"6","author":"Yuan","year":"2020","journal-title":"Sci. Adv."},{"key":"2026080308065044900_cit46","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.bioactmat.2025.10.016","article-title":"Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair","volume":"56","author":"Chen","year":"2026","journal-title":"Bioact. Mater."},{"issue":"3","key":"2026080308065044900_cit47","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.bioactmat.2020.09.012","article-title":"Hybrid gelatin\/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation","volume":"6","author":"Zhou","year":"2021","journal-title":"Bioact. Mater."}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00104","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/15\/6887\/65896130\/mt-2026-00104k.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/15\/6887\/65896130\/mt-2026-00104k.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:14:50Z","timestamp":1785759290000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/9\/15\/6887\/5207658\/A-Biomimetic-Nanocomposite-Hydrogel-Cross-Linked"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":47,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,7,13]]},"published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00104","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}