{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:02:45Z","timestamp":1790107365041,"version":"4.0.1"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recently, substantial interest has emerged in developing point-of-care diagnostic devices for Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by the accumulation of beta-amyloid (A\u03b21\u221242) peptides that act as critical biomarkers for early detection. In response to the growing demand for noninvasive and accessible diagnostic tools, this study presents a highly sensitive organic electrochemical transistor-inspired biosensor for the detection of A\u03b2\u201342 in saliva. The device is based on a paper substrate modified with a PEDOT:GO composite and a Ag-Au nanocomposite, which together enhance electrical conductivity and improve the electrochemical response. A highly selective A\u03b21\u221242-binding aptamer is immobilized on the sensor surface. This platform enables real-time signal amplification, allowing the detection of A\u03b2\u201342 over a dynamic range of 1 pg\/mL to 10 \u03bcg\/mL. This biosensor demonstrates excellent sensitivity, selectivity, and reproducibility, making it a potential tool for noninvasive, point-of-care detection. The use of artificial saliva as a diagnostic medium further enhances its applicability for early screening, especially in decentralized or resource-limited healthcare environments.<\/jats:p>","DOI":"10.1021\/acsabm.6c00105","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:07:00Z","timestamp":1786633620000},"page":"7945-7960","source":"Crossref","is-referenced-by-count":0,"title":["High-Performance Screen-Printed OECT-Inspired with  Encased Cassette Based on PEDOT:GO for Sensitive and Specific Electrochemical Aptasensing of A\u03b2\u201342 in Management of Alzheimer\u2019s Disease"],"prefix":"10.1021","volume":"9","author":[{"given":"Saumitra","family":"Singh","sequence":"first","affiliation":[{"name":"Jamia Hamdard , , ,","place":["New Delhi, India, 110062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakshita","family":"Naithani","sequence":"additional","affiliation":[{"name":"Jamia Hamdard , , ,","place":["New Delhi, India, 110062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Raj","sequence":"additional","affiliation":[{"name":"Symbiosis International University , , ,","place":["Pune, India, 412115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-7363","authenticated-orcid":true,"given":"Jagriti","family":"Narang","sequence":"additional","affiliation":[{"name":"Jamia Hamdard , , ,","place":["New Delhi, India, 110062"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"10","key":"2026092215072437800_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/ADMT.202200153","article-title":"High Performance Organic Electrochemical Transistors and Logic Circuits Manufactured via a Combination of Screen and Aerosol Jet Printing Techniques","volume":"7","author":"Makhinia","year":"2022","journal-title":"Adv. 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