{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:44:00Z","timestamp":1790012640393,"version":"4.0.1"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003151","name":"Fonds de recherche du Qu?bec ? Nature et technologies","doi-asserted-by":"publisher","award":["2021-PR-285621"],"award-info":[{"award-number":["2021-PR-285621"]}],"id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-03902"],"award-info":[{"award-number":["RGPIN-2021-03902"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Bio Mater."],"published-print":{"date-parts":[[2026,6,1]]},"DOI":"10.1021\/acsabm.6c00115","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:25:52Z","timestamp":1779189952000},"page":"4837-4848","source":"Crossref","is-referenced-by-count":2,"title":["Bioactive Nanocomposite Scaffolds by Melt Electrospinning of Poly-\u03b5-Caprolactone\/Polyethylene Oxide\/Polyethylene Glycol-Hydroxyapatite Blends for Bone Tissue Engineering"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0072-9818","authenticated-orcid":true,"given":"Elham","family":"Karimi","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering","place":["Montreal, Canada"]},{"name":"Polytechnique Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoureh Mohseni","family":"Garakani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Orthopaedic Surgery","place":["Montreal, Canada"]},{"name":"McGill University","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-6271","authenticated-orcid":true,"given":"Marie-Claude","family":"Heuzey","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Montreal, Canada"]},{"name":"Polytechnique Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frej","family":"Mighri","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Qu\u00e9bec City, Canada"]},{"name":"Laval University","place":["Qu\u00e9bec City, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek H.","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Orthopaedic Surgery","place":["Montreal, Canada"]},{"name":"McGill University","place":["Montreal, Canada"]},{"name":"Department of Orthopedic Surgery","place":["Farmington, United States"]},{"name":"University of Connecticut School of Medicine","place":["Farmington, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-4538","authenticated-orcid":true,"given":"Abdellah","family":"Ajji","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Montreal, Canada"]},{"name":"Polytechnique Montr\u00e9al","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SM01197J"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2019.1630699"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01613"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14061838"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","unstructured":"Hoveidaei, A. H.; Sadat-Shojai, M.; Nabavizadeh, S. S.; Niakan, R.; Shirinezhad, A.; Mosalamiaghili, S.; Tabaie, S. Clinical challenges in bone tissue engineering-A narrative review.\n                      Bone\n                      2025,\n                      192\n                      , No. 117363 10.1016\/j.bone.2024.117363","DOI":"10.1016\/j.bone.2024.117363"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","unstructured":"Kasi, P. B.; Serafin, A.; O'Brien, L.; Moghbel, N.; Novikov, L. N.; Kelk, P.; Collins, M. N. Electroconductive gelatin\/hyaluronic acid\/hydroxyapatite scaffolds for enhanced cell proliferation and osteogenic differentiation in bone tissue engineering.\n                      Biomater. Adv.\n                      2025,\n                      173\n                      , No. 214286 10.1016\/j.bioadv.2025.214286","DOI":"10.1016\/j.bioadv.2025.214286"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-022-06653-8"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","unstructured":"Pansani, T. N.; Souza Costa, C. A.; Cardoso, L. M.; Claro, A. M.; Barud, H. d. S.; Basso, F. G. Synthesis, characterization, and osteogenic ability of fibrillar polycaprolactone scaffolds containing hydroxyapatite nanoparticles.\n                      ACS Appl. Mater. Interfaces\n                      2025,\n                      17\n                      , 20647\u221220657, 10.1021\/acsami.4c20796","DOI":"10.1021\/acsami.4c20796"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.34172\/apb.43818"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","unstructured":"Dejob, L.; Toury, B.; Tadier, S.; Gremillard, L.; Gaillard, C.; Salles, V. Electrospinning of in situ synthesized silica-based and calcium phosphate bioceramics for applications in bone tissue engineering: A review.\n                      Acta Biomater.\n                      2021,\n                      123\n                      , 123\u2212153, 10.1016\/j.actbio.2020.12.032","DOI":"10.1016\/j.actbio.2020.12.032"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1168504"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","unstructured":"Liang, H.Y.; Lee, W.K.; Hsu, J.T.; Shih, J.Y.; Ma, T.L.; Vo, T. T. T.; Lee, C.W.; Cheng, M.T.; Lee, I.T. Polycaprolactone in bone tissue engineering: a comprehensive review of innovations in scaffold fabrication and surface modifications.\n                      J. Funct. Biomater.\n                      2024,\n                      15\n                      , 243, 10.3390\/jfb15090243","DOI":"10.3390\/jfb15090243"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2018.1465664"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","unstructured":"Cao, Z.; Zhuo, H.; Zhu, W.; Peng, X.; Li, J. Rational construction of PCL-PEG\/CS\/AST nanofiber for bone repair and regeneration.\n                      Front. Bioeng. Biotechnol.\n                      2025,\n                      12\n                      , No. 1515043 10.3389\/fbioe.2024.1515043","DOI":"10.3389\/fbioe.2024.1515043"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","unstructured":"Jahani, A.; Nassira, H. Polyethylene glycol-based materials: Transformative applications in biomedicine and the food industry.\n                      Mater. Chem. Horiz.\n                      2024,\n                      3\n                      , 1074, 10.61186\/MCH.2025.1074","DOI":"10.61186\/MCH.2025.1074"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","unstructured":"Beaudoin, \u00c9. J.; Zednik, R. J.; Demarquette, N. R. Tuning polymer solution elasticity for electrospinning: effects of molecular weight distribution and elastic doping.\n                      Rheol. Acta\n                      2026, 1\u221213, 10.1007\/s00397-025-01541-8","DOI":"10.1007\/s00397-025-01541-8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/pen.70517"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/app.44120"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","unstructured":"Feng, C.; Xue, J.; Yu, X.; Zhai, D.; Lin, R.; Zhang, M.; Xia, L.; Wang, X.; Yao, Q.; Chang, J. Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration.\n                      Acta Biomater.\n                      2021,\n                      119\n                      , 419\u2212431, 10.1016\/j.actbio.2020.11.010","DOI":"10.1016\/j.actbio.2020.11.010"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/ma16144950"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2024.07.266"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/pat.70067"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.5c02123"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/app11041808"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","unstructured":"Robinson, T. M.; Hutmacher, D. W.; Dalton, P. D. The next frontier in melt electrospinning: taming the jet.\n                      Adv. Funct. Mater.\n                      2019,\n                      29\n                      , No. 1904664 10.1002\/adfm.201904664","DOI":"10.1002\/adfm.201904664"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34467"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/machines13090763"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112566"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b02502"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.202100206"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.654518"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.aiepr.2023.09.004"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-017-0889-0"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/app.49401"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2025.02.002"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2024.127844"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","unstructured":"Fredi, G.; Dorigato, A. Compatibilization of biopolymer blends: A review.\n                      Adv. Ind. Eng. Polym. Res.\n                      2024,\n                      7\n                      , 373\u2212404, 10.1016\/j.aiepr.2023.11.002","DOI":"10.1016\/j.aiepr.2023.11.002"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.03.674"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","unstructured":"Mohammadi, M.; Heuzey, M.C.; Carreau, P. J.; Taguet, A. Morphological and rheological properties of PLA, PBAT, and PLA\/PBAT blend nanocomposites containing CNCs.\n                      Nanomaterials\n                      2021,\n                      11\n                      , No. 857 10.3390\/nano11040857","DOI":"10.3390\/nano11040857"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","unstructured":"Bigerelle, M.; Anselme, K. A kinetic approach to osteoblast adhesion on biomaterial surface.\n                      J. Biomed. Mater. Res. A\n                      2005,\n                      75\n                      , 530\u2212540, 10.1002\/jbm.a.30473","DOI":"10.1002\/jbm.a.30473"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","unstructured":"Prime, K. L.; Whitesides, G. M. Self-assembled organic monolayers: Model systems for studying adsorption of proteins at aurfaces.\n                      Science\n                      1991,\n                      252\n                      , 1164\u22121167, 10.1126\/science.252.5009.1164","DOI":"10.1126\/science.252.5009.1164"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.11.026"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.059"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","unstructured":"Zhou, G.; Loppnow, H.; Groth, T. A macrophage\/fibroblast co-culture system using a cell migration chamber to study inflammatory effects of biomaterials.\n                      Acta Biomater.\n                      2015,\n                      26\n                      , 54\u221263, 10.1016\/j.actbio.2015.08.020","DOI":"10.1016\/j.actbio.2015.08.020"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10300"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","unstructured":"Pezzatini, S.; Solito, R.; Morbidelli, L.; Lamponi, S.; Boanini, E.; Bigi, A.; Ziche, M. The effect of hydroxyapatite nanocrystals on microvascular endothelial cell viability and functions.\n                      J. Biomed. Mater. Res. A\n                      2006,\n                      76\n                      , 656\u2212663, 10.1002\/jbm.a.30524","DOI":"10.1002\/jbm.a.30524"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-4-5"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","unstructured":"Sza\u0142aj, U.; Chodara, A.; Gierlotka, S.; Wojnarowicz, J. \u0141ojkowski, W. Enhanced release of calcium ions from hydroxyapatite nanoparticles with an increase in their specific surface area.\n                      Materials\n                      2023,\n                      16\n                      , 6397, 10.3390\/ma16196397","DOI":"10.3390\/ma16196397"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.09.058"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","unstructured":"Foskett, J. K.; White, C.; Cheung, K.H.; Mak, D.O.D. Inositol trisphosphate receptor Ca2+ release channels.\n                      Physiol. Rev.\n                      2007,\n                      87\n                      , 593\u2212658, 10.1152\/physrev.00035.2006","DOI":"10.1152\/physrev.00035.2006"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s2448"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/1754-1611-7-23"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","unstructured":"Garipcan, B.; Maenz, S.; Pham, T.; Settmacher, U.; Jandt, K. D.; Zanow, J.; Bossert, J. Image analysis of endothelial microstructure and endothelial cell dimensions of human arteries\u2212a preliminary study.\n                      Adv. Eng. Mater.\n                      2011,\n                      13\n                      , B54\u2212B57, 10.1002\/adem.201080076","DOI":"10.1002\/adem.201080076"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-012-9459-9"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","unstructured":"Eichholz, K. F.; Hoey, D. A. Mediating human stem cell behaviour via defined fibrous architectures by melt electrospinning writing.\n                      Acta Biomater.\n                      2018,\n                      75\n                      , 140\u2212151, 10.1016\/j.actbio.2018.05.048","DOI":"10.1016\/j.actbio.2018.05.048"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042318"},{"key":"ref57\/cit57","author":"Eichholz K. F.","year":"2019","journal-title":"bioRxiv"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00115","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:10:33Z","timestamp":1780301433000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsabm.6c00115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1021\/acsabm.6c00115"],"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00115","relation":{},"ISSN":["2576-6422","2576-6422"],"issn-type":[{"value":"2576-6422","type":"print"},{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]}}}