{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:54:04Z","timestamp":1781513644672,"version":"3.54.1"},"reference-count":66,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Bio Mater."],"DOI":"10.1021\/acsabm.6c00143","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:22:04Z","timestamp":1779376924000},"source":"Crossref","is-referenced-by-count":0,"title":["Chk1-Targeted Hesperidin Liposomes for Breast Cancer Therapy: An Integrated In Silico,\n                    <i>In Vitro<\/i>\n                    , and\n                    <i>In Vivo<\/i>\n                    Evaluation"],"prefix":"10.1021","author":[{"given":"Nandini","family":"Markuli Sadashivappa","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basavana Gowda","family":"Hosur Dinesh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Ross","family":"Olakkengil Shajan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Bandral","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Ganjipete","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraj","family":"Hanumanthappa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaraj Kumar","family":"Walikar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-5248","authenticated-orcid":true,"given":"Prabu Kumar","family":"Seetharaman","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Xincun West Road 266, Zibo 255000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohankumar","family":"Ramar","sequence":"additional","affiliation":[{"name":"UConn School of Pharmacy and Pharmaceutical Sciences, Storrs, Connecticut 06269, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6741-5118","authenticated-orcid":true,"given":"Selvaraj","family":"Kunjiappan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Alliance University, Anekal, Bengaluru, Karnataka 562106, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-4211","authenticated-orcid":true,"given":"Paruvathanahalli Siddalingam","family":"Rajinikanth","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, Raebareli Road, Lucknow 226025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damodar Nayak","family":"Ammunje","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-4750","authenticated-orcid":true,"given":"Parasuraman","family":"Pavadai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy","place":["Bangalore, India"]},{"name":"M.S. Ramaiah University of Applied Sciences","place":["Bangalore, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1\/ref1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref2\/ref2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref3\/ref3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8010018"},{"key":"ref4\/ref4_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ma00556b"},{"key":"ref5\/ref5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-023-00224-9"},{"key":"ref6\/ref6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.21.13.4129-4139.2001"},{"key":"ref7\/ref7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.03.033"},{"key":"ref8\/ref8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.576"},{"key":"ref9\/ref9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2024.100185"},{"key":"ref10\/ref10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061578"},{"key":"ref11\/ref11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612829666230428110542"},{"key":"ref12\/ref12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16060859"},{"key":"ref13\/ref13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.918665"},{"key":"ref14\/ref14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17902"},{"key":"ref15\/ref15_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.104867"},{"key":"ref16\/ref16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28135152"},{"key":"ref17\/ref17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18030290"},{"key":"ref18\/ref18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.5c00779"},{"key":"ref19\/ref19_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202405635"},{"key":"ref20\/ref20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-95806-0"},{"key":"ref21\/ref21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147982"},{"key":"ref22\/ref22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20657"},{"key":"ref23\/ref23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c08220"},{"key":"ref24\/ref24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"ref25\/ref25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21460"},{"key":"ref26\/ref26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876-024-02694-x"},{"key":"ref27\/ref27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21511"},{"key":"ref28\/ref28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-022-10436-2"},{"key":"ref29\/ref29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28114541"},{"key":"ref30\/ref30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-17733-4"},{"key":"ref31\/ref31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2024.106765"},{"key":"ref32\/ref32_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030543"},{"key":"ref33\/ref33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124705"},{"key":"ref34\/ref34_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2019.16355"},{"key":"ref35\/ref35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c09948"},{"key":"ref36\/ref36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134406"},{"key":"ref37\/ref37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02480-y"},{"key":"ref38\/ref38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107111"},{"key":"ref39\/ref39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104473"},{"key":"ref40\/ref40_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.108"},{"key":"ref41\/ref41_1","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.374"},{"key":"ref42\/ref42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2022.105144"},{"key":"ref43\/ref43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01806074"},{"key":"ref44\/ref44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031077"},{"key":"ref45\/ref45_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17-0497"},{"key":"ref46\/ref46_1","doi-asserted-by":"publisher","DOI":"10.21275\/SUB154001"},{"key":"ref47\/ref47_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.56.3s.157"},{"key":"ref48\/ref48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2022.100196"},{"key":"ref49\/ref49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115445"},{"key":"ref50\/ref50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.06.048"},{"key":"ref51\/ref51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-14-23"},{"key":"ref52\/ref52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15020211"},{"key":"ref53\/ref53_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400295a"},{"key":"ref54\/ref54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c03233"},{"key":"ref55\/ref55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026878"},{"key":"ref56\/ref56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00635"},{"key":"ref57\/ref57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041631"},{"key":"ref58\/ref58_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450120666190923162203"},{"key":"ref59\/ref59_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020174"},{"key":"ref60\/ref60_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2021.1979673"},{"key":"ref61\/ref61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.1c00779"},{"key":"ref62\/ref62_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2020.201103"},{"key":"ref63\/ref63_1","doi-asserted-by":"publisher","DOI":"10.4314\/sokjmls.v7i1.11"},{"key":"ref64\/ref64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01181-4"},{"key":"ref65\/ref65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02198-8"},{"key":"ref66\/ref66_1","doi-asserted-by":"publisher","DOI":"10.5603\/mrj.a2018.0039"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00143","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:10:56Z","timestamp":1781511056000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsabm.6c00143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":66,"alternative-id":["10.1021\/acsabm.6c00143"],"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00143","relation":{},"ISSN":["2576-6422","2576-6422"],"issn-type":[{"value":"2576-6422","type":"print"},{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"article-number":"acsabm.6c00143"}}