{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:18:46Z","timestamp":1783329526757,"version":"3.54.6"},"reference-count":70,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100021131","name":"Azrieli College of Engineering Jerusalem","doi-asserted-by":"publisher","award":["SM2024-2025"],"award-info":[{"award-number":["SM2024-2025"]}],"id":[{"id":"10.13039\/100021131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Bio Mater."],"DOI":"10.1021\/acsabm.6c00235","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:21:04Z","timestamp":1781691664000},"source":"Crossref","is-referenced-by-count":0,"title":["Dissolving Microneedles for Transdermal Delivery of Melatonin: Fabrication, Characterization, and In Vivo Pharmacokinetic Evaluation in Mice"],"prefix":"10.1021","author":[{"given":"Hadar","family":"Nimni","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering","place":["Jerusalem, Israel"]},{"name":"Azrieli College of Engineering Jerusalem","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5290-9000","authenticated-orcid":true,"given":"Vladislav","family":"Nesterenko","sequence":"additional","affiliation":[{"name":"The Institute for Drug Research, School of Pharmacy, Faculty of Medicine","place":["Jerusalem, Israel"]},{"name":"Hebrew University of Jerusalem","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeen","family":"Bader","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering","place":["Jerusalem, Israel"]},{"name":"Azrieli College of Engineering Jerusalem","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Sheeni","sequence":"additional","affiliation":[{"name":"The Institute for Drug Research, School of Pharmacy, Faculty of Medicine","place":["Jerusalem, Israel"]},{"name":"Hebrew University of Jerusalem","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfeeq","family":"Shekh-Ahmad","sequence":"additional","affiliation":[{"name":"The Institute for Drug Research, School of Pharmacy, Faculty of Medicine","place":["Jerusalem, Israel"]},{"name":"Hebrew University of Jerusalem","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-3120","authenticated-orcid":true,"given":"Aiman","family":"Abu Ammar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering","place":["Jerusalem, Israel"]},{"name":"Azrieli College of Engineering Jerusalem","place":["Jerusalem, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2021.04.002"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.17.3.212"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010072"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.683047"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.883637"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-023-01324-w"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S361519"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00962.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666161228122115"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-016-0052-2"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-023-00431-9"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.109"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2023.101252"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e08938"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.078"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.025"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/mi12111321"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c01133"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162815"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.10.022"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.10.013"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.106697"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2023.2285498"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.12.007"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020526"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106391"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.045"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118098"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010289"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041109"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/D4MA00908H"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.35812\/CelluloseChemTechnol.2024.58.28"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/polym16040452"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.11.019"},{"key":"ref35\/cit35","author":"PubChem","journal-title":"Melatonin"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01143C"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.123826"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125143"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.07.009"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.05.017"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.05.042"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.18596\/jotcsa.30880"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101601"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18542"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-021-00611-9"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213889"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.07.010"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01426-5"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.05.143"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2017.04.001"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13122198"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/polym16162377"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.22146\/ijc.21324"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.5530\/jyp.2023.15.42"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1080\/17435889.2024.2379757"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1039\/D2CP05972J"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.tca.2012.03.010"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061335"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.113371"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2019.1624373"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s44323-024-00013-1"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1177\/074873098129000228"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079x.1997.tb00302.x"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2017-0005"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140500"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201400017"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12509"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00360.2001"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-025-03139-y"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1599-1"}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00235","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:43:15Z","timestamp":1783327395000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsabm.6c00235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":70,"alternative-id":["10.1021\/acsabm.6c00235"],"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00235","relation":{},"ISSN":["2576-6422","2576-6422"],"issn-type":[{"value":"2576-6422","type":"print"},{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"article-number":"acsabm.6c00235"}}