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Current preventive strategies based on antibiotics are increasingly challenged by the emergence of antimicrobial resistance, while complex surface modification approaches often suffer from limited practicality and translational barriers. In this study, we propose the integration of a structurally complex, tetra-branched antimicrobial peptide (SET-M33) within a gelatin methacryloyl (GelMA) hydrogel to create an antimicrobial-releasing coating for CIED surfaces. By tuning the properties of the GelMA matrix, we achieved controlled peptide release tailored to clinically relevant timeframes. The resulting M33-GelMA coating demonstrated strong in\u00a0vitro efficacy in preventing bacterial growth and adhesion by six clinically relevant pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter baumannii, Escherichia coli, Enterococcus faecium, Stenotrophomonas maltophilia), achieving up to a 9-log reduction in bacterial load. Overall, this work provides a practical and translatable strategy for leveraging more stable, next-generation antimicrobial peptides to reduce postoperative CIED infections and associated healthcare burdens.<\/jats:p>","DOI":"10.1021\/acsabm.6c00341","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:02:16Z","timestamp":1786636936000},"page":"7961-7974","source":"Crossref","is-referenced-by-count":0,"title":["Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9696-4119","authenticated-orcid":true,"given":"Alessia","family":"Maranesi","sequence":"first","affiliation":[{"name":"Unitat mixta d\u2019Investigaci\u00f3 IRTA-UAB en Sanitat Animal , Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB) , , ,","place":["Bellaterra, Catalonia, Spain, 08193"]},{"name":", Campus de la Universitat Aut\u00f2noma de Barcelona (UAB) , , ,","place":["Bellaterra, Catalonia, Spain, 08193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Hylomorph AG , ,","place":["Zurich, Switzerland, 8005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-8482","authenticated-orcid":true,"given":"Chiara","family":"Falciani","sequence":"additional","affiliation":[{"name":"SetLance srl , ,","place":["Siena, Italy, 53100"]},{"name":"University of Siena , , ,","place":["Siena, Italy, 53100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[{"name":"SetLance srl , ,","place":["Siena, Italy, 53100"]},{"name":"University of Siena , , ,","place":["Siena, Italy, 53100"]},{"name":"Azienda Ospedaiera Universitaria Senese , , ,","place":["Siena, Italy, 53100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kochanowski","sequence":"additional","affiliation":[{"name":"Unitat mixta d\u2019Investigaci\u00f3 IRTA-UAB en Sanitat Animal , Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB) , , ,","place":["Bellaterra, Catalonia, Spain, 08193"]},{"name":", Campus de la Universitat Aut\u00f2noma de Barcelona (UAB) , , ,","place":["Bellaterra, Catalonia, Spain, 08193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1299","authenticated-orcid":true,"given":"Marta","family":"Cerd\u00e0-Cu\u00e9llar","sequence":"additional","affiliation":[{"name":"Unitat mixta d\u2019Investigaci\u00f3 IRTA-UAB en Sanitat Animal , Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Aut\u00f2noma de Barcelona (UAB) , , ,","place":["Bellaterra, Catalonia, Spain, 08193"]},{"name":", Campus de la Universitat Aut\u00f2noma de Barcelona (UAB) , , ,","place":["Bellaterra, Catalonia, Spain, 08193"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026092215071499200_cit1","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/j.1540-8159.2011.03150.x","article-title":"The 11th world survey of cardiac pacing and implantable cardioverter-defibrillators: Calendar year 2009 - A world society of Arrhythmia\u2019s project","volume":"34","author":"Mond","year":"2011","journal-title":"Pacing Clin. 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