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Here, zinc metal particle-embedded polycaprolactone (PZ) electrospun nanofiber scaffolds were evaluated as an immunomodulatory platform that directs protein expression to influence the wound healing process. Scaffolds containing 0, 0.5, and 1 wt % Zn were assessed during fibroblast monoculture, macrophage monoculture, and fibroblast-macrophage coculture models under sustained inflammatory stimulation. Zn incorporation enhanced cell viability and metabolic activity while maintaining low cytotoxicity across all culture systems. Fibroblasts cultured on Zn-containing scaffolds exhibited reduced inflammatory signaling, suppressed COX-2 expression, and increased secretion of proangiogenic and pro-proliferative factors such as EGF, bFGF, and VEGF. Macrophages displayed restrained inflammatory activation, accompanied by elevated growth factor output, consistent with a pro-healing phenotype. Coculture studies revealed that Zn scaffolds selectively dampened inflammatory amplification while preserving cooperative angiogenic signaling, evidenced by reduced IL-6 and COX-2 expression. Altogether, these results establish Zn-embedded PCL scaffolds as a tunable platform for directing inflammatory and regenerative signaling relevant to wound healing applications.<\/jats:p>","DOI":"10.1021\/acsabm.6c00391","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:25:15Z","timestamp":1788470715000},"page":"8427-8443","source":"Crossref","is-referenced-by-count":0,"title":["<i>In Vitro<\/i>\n                    Wound Healing Evaluation of Zinc Particle-Embedded Nanofibrous Scaffolds through Protein Expression Profiling"],"prefix":"10.1021","volume":"9","author":[{"given":"Alexis","family":"Moody","sequence":"first","affiliation":[{"name":"North Carolina A&T State University , , , ,","place":["Greensboro, North Carolina, USA, 27411"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-7913","authenticated-orcid":true,"given":"Narayan","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"North Carolina A&T State University , , , ,","place":["Greensboro, North Carolina, USA, 27411"]},{"name":"North Carolina A&T State University , , , ,","place":["Greensboro, North Carolina, USA, 27411"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026092100085252000_cit1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.bioactmat.2023.11.012","article-title":"Developing natural polymers for skin wound healing","volume":"33","author":"Zhang","year":"2024","journal-title":"Bioact. 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