{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T09:30:03Z","timestamp":1793611803813,"version":"4.5.0"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"21","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["307471\/2021-7"],"award-info":[{"award-number":["307471\/2021-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["405705\/2025-5"],"award-info":[{"award-number":["405705\/2025-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/07353-5"],"award-info":[{"award-number":["2022\/07353-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/16267-5"],"award-info":[{"award-number":["2022\/16267-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2023\/17123-0"],"award-info":[{"award-number":["2023\/17123-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2025\/01671-3"],"award-info":[{"award-number":["2025\/01671-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Implant manufacturing routes determine surface architecture and, consequently, modulate biointerface interactions that govern early biological responses. Although additive manufacturing has emerged as a promising alternative to conventional subtractive techniques, direct comparisons among commercially available systems remain limited. In this study, a commercially available additively manufactured dental implant was compared with four market-available conventionally machined systems to elucidate manufacturing route-dependent biointerface modulation. Physicochemical properties, surface topography, and electrochemical behavior were evaluated alongside biological responses. Protein adsorption profiles were characterized by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS), while polymicrobial accumulation was quantified and profiled. Microbially induced surface degradation was assessed by titanium ion release. The additively manufactured implant and the market-leading conventional system exhibited higher surface roughness and distinctive topographical features, which were associated with reduced polymicrobial biofilm accumulation, lower titanium ion release following microbial challenge, and stable electrochemical behavior. Although conventionally machined implants exhibited broader proteomic profiles, functional enrichment analyses revealed overlapping biological categories among implant systems. Collectively, the findings demonstrate that the manufacturing route critically modulates implant biointerface characteristics, with additive manufacturing achieving performance comparable to established commercial systems.<\/jats:p>","DOI":"10.1021\/acsabm.6c00473","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:03:12Z","timestamp":1791817392000},"page":"10090-10106","source":"Crossref","is-referenced-by-count":0,"title":["Manufacturing Route-Dependent Biointerface Modulation in 3D-Printed and Conventional Dental Implant Systems"],"prefix":"10.1021","volume":"9","author":[{"given":"Maria Helena Rossy","family":"Borges","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Piracicaba, Sa\u0303o Paulo, Brazil, 13414-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio da Costa","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade Universus Veritas Guarulhos , , ,","place":["Guarulhos, Brazil, 07023-070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Nascimento","family":"Souza","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein , , ,","place":["Sa\u0303o Paulo, Brazil, 05653-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Rafael Mangueira","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Dental Science School (Faculdade de Ci\u00eancias Odontol\u00f3gicas) , ,","place":["Montes Claros, Brazil, 39401-303"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia Sufia Alves Freire","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Piracicaba, Sa\u0303o Paulo, Brazil, 13414-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnaldo R.","family":"de Souza Junior","sequence":"additional","affiliation":[{"name":"State University of Montes Claros , , ,","place":["Montes Claros, Brazil, 39401-832"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aljomar Jos\u00e9","family":"Vechiato-Filho","sequence":"additional","affiliation":[{"name":"Universidade Universus Veritas Guarulhos , , ,","place":["Guarulhos, Brazil, 07023-070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-9917","authenticated-orcid":true,"given":"Valentim A. R.","family":"Bar\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Piracicaba, Sa\u0303o Paulo, Brazil, 13414-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil A.","family":"Shibli","sequence":"additional","affiliation":[{"name":"Universidade Universus Veritas Guarulhos , , ,","place":["Guarulhos, Brazil, 07023-070"]},{"name":"Hospital Israelita Albert Einstein , , ,","place":["Sa\u0303o Paulo, Brazil, 05653-000"]},{"name":"Periodontology and Oral Microbiology, KU Leuven , , ,","place":["Leuven, Belgium, 3000"]},{"name":"Harvard School of Dental Medicine , , , ,","place":["Boston, Massachusetts, USA, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-6953","authenticated-orcid":true,"given":"Jo\u00e3o Gabriel S.","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Piracicaba, Sa\u0303o Paulo, Brazil, 13414-903"]},{"name":"Universidade Universus Veritas Guarulhos , , ,","place":["Guarulhos, Brazil, 07023-070"]},{"name":"Hospital Israelita Albert Einstein , , ,","place":["Sa\u0303o Paulo, Brazil, 05653-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"issue":"77","key":"2026110201075141200_cit1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/prd.12211","article-title":"Implant placement in the esthetic area: criteria for positioning single and multiple implants","volume":"2018","author":"Testori","journal-title":"Periodontol. 2000"},{"key":"2026110201075141200_cit2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ijom.2014.10.023","article-title":"Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review","volume":"44","author":"Moraschini","year":"2015","journal-title":"Int. J. Oral. Maxillofac. Surg."},{"key":"2026110201075141200_cit3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2018.08.013","article-title":"A critical review of multifunctional titanium surfaces: New frontiers for improving osseointegration and host response, avoiding bacteria contamination","volume":"79","author":"Spriano","year":"2018","journal-title":"Acta. Biomater."},{"key":"2026110201075141200_cit4","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12637","article-title":"Engineered surface strategies to manage dental implant-related infections","author":"Souza","year":"2025","journal-title":"Periodontol. 2000"},{"key":"2026110201075141200_cit5","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.dental.2006.06.025","article-title":"Surface treatments of titanium dental implants for rapid osseointegration","volume":"23","author":"Le Gu\u00e9hennec","year":"2007","journal-title":"Dent. Mater."},{"key":"2026110201075141200_cit6","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.1016\/j.biomaterials.2008.05.012","article-title":"Advancing dental implant surface technology\u2014from micron- to nanotopography","volume":"29","author":"Mendon\u00e7a","year":"2008","journal-title":"Biomaterials"},{"issue":"73","key":"2026110201075141200_cit7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12185","article-title":"Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions","author":"Buser","year":"2017","journal-title":"Periodontol. 2000"},{"key":"2026110201075141200_cit8","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00170-022-08770-8","article-title":"A comprehensive review on metallic implant biomaterials and their subtractive manufacturing","volume":"120","author":"Davis","year":"2022","journal-title":"Int. J. Adv. Manuf. Technol."},{"key":"2026110201075141200_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2024.e00356","article-title":"Advanced additive manufacturing in implant dentistry: 3D printing technologies, printable materials, current applications and future requirements","volume":"42","author":"Alqutaibi","year":"2024","journal-title":"Bioprinting"},{"key":"2026110201075141200_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.104925","article-title":"3D-printed versus conventionally milled zirconia for dental clinical applications: Trueness, precision, accuracy, biological and esthetic aspects","volume":"144","author":"Alghauli","year":"2024","journal-title":"J. Dent."},{"key":"2026110201075141200_cit11","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/sj.bdj.2015.914","article-title":"3D printing in dentistry","volume":"219","author":"Dawood","year":"2015","journal-title":"Br. Dent. J."},{"key":"2026110201075141200_cit12","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/jopr.13212","article-title":"A Review of the Applications of Additive Manufacturing Technologies Used to Fabricate Metals in Implant Dentistry","volume":"29","author":"Revilla-Le\u00f3n","year":"2020","journal-title":"J. Prosthodont."},{"issue":"26","key":"2026110201075141200_cit13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/clr.14085","article-title":"Additively and subtractively manufactured implant-supported fixed dental prostheses: A systematic review","volume":"34","author":"Ioannidis","year":"2023","journal-title":"Clin. Oral. Implants. Res."},{"key":"2026110201075141200_cit14","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40729-024-00521-6","article-title":"Clinical performance of additively manufactured subperiosteal implants: a systematic review","volume":"10","author":"Anitua","year":"2024","journal-title":"Int. J. Implant. Dent."},{"key":"2026110201075141200_cit15","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5373-mr-2023-0448","article-title":"Evaluation of Osteoblastic Differentiation Induced by Microtextured Titanium Surface Produced by Laser Metal Fusion 3D Printing","volume":"27","author":"Lopes","year":"2024","journal-title":"Mater. Res."},{"key":"2026110201075141200_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17105","article-title":"Osseointegration in additive-manufactured titanium implants: A systematic review of animal studies on the need for surface treatment","volume":"9","author":"Calazans Neto","year":"2023","journal-title":"Heliyon"},{"key":"2026110201075141200_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35508","article-title":"Atomic Interaction S. aureus\/Machined and Additive Manufacturing Ti-6Al-4V and Ti-35Nb-7Zr-5Ta Disks for Dental Implants","volume":"112","author":"Tardelli","year":"2024","journal-title":"J. Biomed. Mater. Res., Part B"},{"key":"2026110201075141200_cit18","doi-asserted-by":"publisher","first-page":"23393","DOI":"10.1021\/acsnano.5c06573","article-title":"Exploring the Impact of Biotic and Abiotic Surfaces on Protein Binding Modulation and Bacteria Attachment: Integrating Biological and Mathematical Approaches","volume":"19","author":"Souza","year":"2025","journal-title":"ACS. Nano"},{"key":"2026110201075141200_cit19","doi-asserted-by":"publisher","first-page":"10118","DOI":"10.1021\/acsami.9b22741","article-title":"Targeting Pathogenic Biofilms: Newly Developed Superhydrophobic Coating Favors a Host-Compatible Microbial Profile on the Titanium Surface","volume":"12","author":"Souza","year":"2020","journal-title":"ACS. Appl. Mater. Interfaces."},{"key":"2026110201075141200_cit20","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.1021\/acsbiomaterials.3c00491","article-title":"Boosting Titanium Surfaces with Positive Charges: Newly Developed Cationic Coating Combines Anticorrosive and Bactericidal Properties for Implant Application","volume":"9","author":"Silva","year":"2023","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"2026110201075141200_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2022.101095","article-title":"A tattoo-inspired electrosynthesized polypyrrole film: crossing the line toward a highly adherent film for biomedical implant applications","volume":"26","author":"Borges","year":"2022","journal-title":"Mater. Today Chem."},{"key":"2026110201075141200_cit22","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1111\/j.1600-0501.2011.02265.x","article-title":"Stability of cp-Ti and Ti-6Al-4V alloy for dental implants as a function of saliva pH \u2013 an electrochemical study","volume":"23","author":"Bar\u00e3o","year":"2012","journal-title":"Clin. Oral Implants Res."},{"key":"2026110201075141200_cit23","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1159\/000446407","article-title":"Calcium prerinse before fluoride rinse reduces enamel demineralization: an in situ caries study","volume":"50","author":"Souza","year":"2016","journal-title":"Caries Res."},{"key":"2026110201075141200_cit24","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/08927014.2019.1580360","article-title":"Proteome analysis of the salivary pellicle formed on titanium alloys containing niobium and zirconium","volume":"35","author":"Pantaroto","year":"2019","journal-title":"Biofouling"},{"key":"2026110201075141200_cit25","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1021\/acs.jproteome.2c00652","article-title":"Effect of processing methods of human saliva on the proteomic profile and protein-mediated biological processes","volume":"22","author":"Miranda","year":"2023","journal-title":"J. Proteome Res."},{"key":"2026110201075141200_cit26","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.archoralbio.2009.01.011","article-title":"Small molecular weight proteins\/peptides present in the in vivo formed human acquired enamel pellicle","volume":"54","author":"Siqueira","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"2026110201075141200_cit27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/08927014.2020.1769613","article-title":"Proteomic profile of the saliva and plasma protein layer adsorbed on Ti\u2013Zr alloy: the effect of sandblasted and acid-etched surface treatment","volume":"36","author":"Souza","year":"2020","journal-title":"Biofouling"},{"key":"2026110201075141200_cit28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jprot.2016.03.036","article-title":"Global proteome profiling of dental cementum under experimentally-induced apposition","volume":"141","author":"Salmon","year":"2016","journal-title":"J. Proteomics"},{"key":"2026110201075141200_cit29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinf."},{"key":"2026110201075141200_cit30","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1080\/08927014.2018.1557151","article-title":"Dose-response effect of chlorhexidine on a multispecies oral biofilm formed on pure titanium and on a titanium-zirconium alloy","volume":"34","author":"Souza","year":"2018","journal-title":"Biofouling"},{"key":"2026110201075141200_cit31","doi-asserted-by":"publisher","DOI":"10.1093\/jambio\/lxad265","article-title":"In-vitro polymicrobial oral biofilm model represents clinical microbial profile and disease progression during implant-related infections","volume":"134","author":"Dini","year":"2023","journal-title":"J. Appl. Microbiol."},{"key":"2026110201075141200_cit32","first-page":"788","article-title":"\u201cCheckerboard\u201d DNA\u2013DNA hybridization","volume":"17","author":"Socransky","year":"1994","journal-title":"Biotechniques"},{"key":"2026110201075141200_cit33","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/clr.14224","article-title":"Efficacy of a novel three-step decontamination protocol for titanium-based dental implants: An in vitro and in vivo study","volume":"35","author":"Costa","year":"2024","journal-title":"Clin. Oral Implants Res."},{"key":"2026110201075141200_cit34","volume-title":"NIST Database for the Simulation of Electron Spectra for Surface Analysis, Version 2.0, Standard Reference Data Program Database 100","author":"Werner","year":"2014"},{"key":"2026110201075141200_cit35","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jcis.2020.06.102","article-title":"Synthesis of bioactive glass-based coating by plasma electrolytic oxidation: untangling a new deposition pathway toward titanium implant surfaces","volume":"579","author":"Costa","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"2026110201075141200_cit36","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1600-0501.2009.01828.x","article-title":"A randomized clinical 1-year trial comparing two types of non-submerged dental implants","volume":"21","author":"Park","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"2026110201075141200_cit37","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1021\/acsbiomaterials.3c01809","article-title":"Surface topography has less influence on peri-implantitis than patient factors: a comparative clinical study of two dental implant systems","volume":"10","author":"Hussain","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"2026110201075141200_cit38","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3390\/medicina60101614","article-title":"Immediate loading full-arch 3D-printed implant-supported fixed rehabilitation: a case report with 24-month follow-up","volume":"60","author":"de Carvalho Formiga","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"2026110201075141200_cit39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3290\/j.ijcd.b4870843","article-title":"3D printing\/additive manufacturing of single-implant overdentures: a randomized controlled clinical trial","volume":"28","author":"Ibrahim","year":"2025","journal-title":"Int. J. Comput. Dent."},{"key":"2026110201075141200_cit40","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1177\/154405910608500603","article-title":"Implant surface roughness and bone healing: a systematic review","volume":"85","author":"Shalabi","year":"2006","journal-title":"J. Dent. Res."},{"issue":"3","key":"2026110201075141200_cit41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3390\/bioengineering13030299","article-title":"Implant Surface Characteristics and Peri-Implant Outcomes: A Systematic Review of Clinical and Microbiological Evidence","volume":"13","author":"Dipalma","year":"2026","journal-title":"Bioengineering"},{"issue":"4","key":"2026110201075141200_cit42","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1600-0501.2009.01775.x","article-title":"Effects of titanium surface topography on bone integration: a systematic review","volume":"20","author":"Wennerberg","year":"2009","journal-title":"Clin. Oral. Implants. Res."},{"key":"2026110201075141200_cit43","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1016\/S0142-9612(98)00144-6","article-title":"Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition","volume":"19","author":"Lincks","year":"1998","journal-title":"Biomaterials"},{"key":"2026110201075141200_cit44","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1016\/j.corsci.2011.02.025","article-title":"Super-hydrophobic film prepared on zinc as corrosion barrier","volume":"53","author":"Wang","year":"2011","journal-title":"Corros. Sci."},{"key":"2026110201075141200_cit45","doi-asserted-by":"publisher","first-page":"11844","DOI":"10.1016\/j.ceramint.2015.05.153","article-title":"A comparative study of the corrosion performance of titanium (Ti), titanium nitride (TiN), titanium dioxide (TiO2) and nitrogen-doped titanium oxides (N\u2013TiO2), as coatings for biomedical applications","volume":"41","author":"Wang","year":"2015","journal-title":"Ceram. Int."},{"issue":"7","key":"2026110201075141200_cit46","doi-asserted-by":"publisher","first-page":"7076","DOI":"10.1007\/s11665-025-12091-8","article-title":"Corrosion characterization of Ti-6Al-4V alloy after constrained groove pressing and TiO2 coating","volume":"35","author":"Bencherifa","year":"2026","journal-title":"J. Mater. Eng. Perform."},{"key":"2026110201075141200_cit47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cis.2010.12.007","article-title":"Understanding protein adsorption phenomena at solid surfaces","volume":"162","author":"Rabe","year":"2011","journal-title":"Adv. Colloid. Interface. Sci."},{"key":"2026110201075141200_cit48","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.colsurfb.2009.05.028","article-title":"Non-specific adhesion on biomaterial surfaces driven by small amounts of protein adsorption","volume":"73","author":"Kalasin","year":"2009","journal-title":"Colloids Surf., B"},{"key":"2026110201075141200_cit49","doi-asserted-by":"publisher","first-page":"8168","DOI":"10.1021\/ja042898o","article-title":"Interpretation of protein adsorption: surface-induced conformational changes","volume":"127","author":"Roach","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"2026110201075141200_cit50","doi-asserted-by":"publisher","first-page":"6692","DOI":"10.1016\/j.biomaterials.2011.05.078","article-title":"Immune responses to implants \u2013 a review of the implications for the design of immunomodulatory biomaterials","volume":"32","author":"Franz","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"2026110201075141200_cit51","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2025.2607199","article-title":"Influence of dental implant surfaces on oral biofilms and host immune response","volume":"18","author":"Vernon","year":"2026","journal-title":"J. Oral Microbiol."},{"key":"2026110201075141200_cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.102008","article-title":"Targeting implant-associated infections: titanium surface loaded with antimicrobial","volume":"24","author":"Souza","year":"2021","journal-title":"iScience"},{"key":"2026110201075141200_cit53","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1177\/0022034511399096","article-title":"Stick to your gums: mechanisms of oral microbial adherence","volume":"90","author":"Nobbs","year":"2011","journal-title":"J. Dent. Res."},{"key":"2026110201075141200_cit54","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.biomaterials.2010.10.001","article-title":"Differential response of staphylococci and osteoblasts to varying titanium surface roughness","volume":"32","author":"Wu","year":"2011","journal-title":"Biomaterials"},{"key":"2026110201075141200_cit55","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1177\/0022034515587690","article-title":"Effects of material properties on bacterial adhesion and biofilm formation","volume":"94","author":"Song","year":"2015","journal-title":"J. Dent. Res."},{"key":"2026110201075141200_cit56","doi-asserted-by":"publisher","first-page":"27685","DOI":"10.3402\/jom.v7.27685","article-title":"Osseointegrated implants placed at supracrestal level may harbour higher counts of A. gerencseriae and S. constellatus \u2013 a randomized, controlled pilot study","volume":"7","author":"de Moraes Rego","year":"2015","journal-title":"J. Oral. Microbiol."},{"key":"2026110201075141200_cit57","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/dj13040148","article-title":"Exploring Peri-Implantitis Risk-Factors: A Cross-Sectional Study","volume":"13","author":"Iu\u0219an","year":"2025","journal-title":"Dent. J."},{"key":"2026110201075141200_cit58","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41522-020-00155-7","article-title":"Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics","volume":"6","author":"Ghensi","year":"2020","journal-title":"NPJ. Biofilms. Microbiomes."},{"key":"2026110201075141200_cit59","doi-asserted-by":"publisher","first-page":"20774","DOI":"10.1007\/s10853-026-13050-x","article-title":"Review: Advances in implant material design and surface engineering for optimised soft- and hard-tissue integration","volume":"61","author":"Singh","year":"2026","journal-title":"J. Mater. Sci."}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00473","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/21\/10090\/68822014\/mt-2026-00473p.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/21\/10090\/68822014\/mt-2026-00473p.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T09:09:20Z","timestamp":1793610560000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/9\/21\/10090\/5449132\/Manufacturing-Route-Dependent-Biointerface"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":59,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2026,10,12]]},"published-print":{"date-parts":[[2026,11,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00473","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]}}}