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Nitric oxide (NO) and carbon monoxide (CO) serve as pivotal gaseous signaling molecules, with elevated NO levels linked to disease exacerbation, while low-dose CO exerts anti-inflammatory effects. In this study, we engineered a dual gas-regulating micelle (DGRM) nanoplatform capable of simultaneously scavenging NO and releasing CO. In an LPS-stimulated macrophage inflammation model, DGRM demonstrated excellent biocompatibility, effectively eliminated NO and reactive oxygen species (ROS), and markedly inhibited the production of pro-inflammatory cytokines (IL-6 and IFN-\u03b3). Furthermore, in an ovalbumin (OVA)-induced allergic asthma murine model, nebulized DGRM administration exhibited pronounced therapeutic effects. Mechanistic investigations revealed that DGRM downregulated inducible nitric oxide synthase (iNOS) while upregulating heme oxygenase-1 (HO-1), thereby modulating the iNOS\/HO-1\/CO signaling axis. These findings collectively indicate that DGRM effectively mitigates airway inflammation in allergic asthma, offering a gasotransmitter-based nanotherapeutic approach for asthma management.<\/jats:p>","DOI":"10.1021\/acsabm.6c00590","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T11:01:43Z","timestamp":1786273303000},"page":"8444-8455","source":"Crossref","is-referenced-by-count":0,"title":["Inflammation-Responsive NO-Scavenging and CO-Releasing Micelles Alleviate Pulmonary Inflammation and Th2 Cytokine Production in Asthma"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4143-538X","authenticated-orcid":true,"given":"Daoxiang","family":"Rong","sequence":"first","affiliation":[{"name":"the First Affiliated Hospital of Bengbu Medical University , , , ,","place":["Bengbu, Anhui, China, 233004"]},{"name":"the First Affiliated Hospital of Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Wang","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Bengbu Medical University , , , ,","place":["Bengbu, Anhui, China, 233004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Bengbu Medical University , , , ,","place":["Bengbu, Anhui, China, 233004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihan","family":"Zheng","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohu","family":"Huo","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Zhu","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenggang","family":"Ding","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Anhui Medical University , , , ,","place":["Hefei, Anhui, China, 230022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Bengbu Medical University , , , ,","place":["Bengbu, Anhui, China, 233004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"issue":"5","key":"2026092100082660100_cit1","first-page":"364","article-title":"Update on Asthma Management Guidelines","volume":"121","author":"Dubin","year":"2024","journal-title":"Mo. 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