{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:15:04Z","timestamp":1789992904433,"version":"4.0.1"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"18","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["RTC-2017-6668-1"],"award-info":[{"award-number":["RTC-2017-6668-1"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ag?ncia de Gesti? d?Ajuts Universitaris i de Recerca","award":["2016-DI073"],"award-info":[{"award-number":["2016-DI073"]}]},{"name":"Ag?ncia de Gesti? d?Ajuts Universitaris i de Recerca","award":["SGR-1559"],"award-info":[{"award-number":["SGR-1559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacterial colonization and biofilm formation remain major limitations of airway stenting, contributing to device obstruction and infection-related complications. Here, we translated to silicone tracheal stents a previously developed plasma-assisted micro\/nanostructured silver interface designed to provide hybrid anti-biofilm activity through reduced bacterial adhesion and controlled silver release. The coated stents were characterized to confirm the generation of the nanostructured silver coating and were evaluated against Gram-positive and Gram-negative bacteria in vitro, followed by in vivo assessment in a miniature pig airway model. In vitro, the coating reproduced the dual bacteriophobic and silver-mediated antimicrobial behavior previously observed on model silicone surfaces. In vivo, animals implanted with silver-coated stents showed lower endpoint bacterial loads in bronchial washes than those receiving commercial stents (1.0 \u00d7 108 vs 1.2 \u00d7 109 CFU\/mL, p =0.0085). Bacterial adhesion on explanted stents was also markedly lower for coated devices (109 vs 1011 CFU \/cm2, 99.8% reduction, p &amp;lt; 0.0001), and scanning electron microscopy showed a thinner and less mature biofilm structure. Potentially pathogenic bacteria, including Klebsiella pneumoniae and Pseudomonas aeruginosa, were more frequently detected on commercial stents, whereas coated stents were mainly associated with the native respiratory microbiota. Overall, these results indicate that nanostructured silver-coated silicone tracheal stents display hybrid anti-biofilm functionality in a challenging in vivo airway setting.<\/jats:p>","DOI":"10.1021\/acsabm.6c00591","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:14:53Z","timestamp":1788452093000},"page":"8456-8470","source":"Crossref","is-referenced-by-count":0,"title":["Nanostructured Silver-Coated Silicone Tracheal Stents Confer Hybrid Anti-Biofilm Activity In Vivo"],"prefix":"10.1021","volume":"9","author":[{"given":"Cristina","family":"Garcia-Bonillo","sequence":"first","affiliation":[{"name":"Universidad Europea de Valencia , ,","place":["Valencia, Spain, 46010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"L\u00f3pez-Lisbona","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona , , ,","place":["Hospitalet de Llobregat, Barcelona, Spain, 08907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"D\u00edez-Ferrer","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona , , ,","place":["Hospitalet de Llobregat, Barcelona, Spain, 08907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Marti","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona , , ,","place":["Hospitalet de Llobregat, Barcelona, Spain, 08907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Gilabert","sequence":"additional","affiliation":[{"name":"Institut Qu\u00edmic de Sarri\u00e0 (IQS), Universitat Ramon Llull , , Via Augusta 390 ,","place":["Barcelona, Spain, 08017"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Cubero","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona , , ,","place":["Hospitalet de Llobregat, Barcelona, Spain, 08907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salud","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona , , ,","place":["Hospitalet de Llobregat, Barcelona, Spain, 08907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-0381","authenticated-orcid":true,"given":"Salvador","family":"Borr\u00f3s","sequence":"additional","affiliation":[{"name":"Institut Qu\u00edmic de Sarri\u00e0 (IQS), Universitat Ramon Llull , , Via Augusta 390 ,","place":["Barcelona, Spain, 08017"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-7191","authenticated-orcid":true,"given":"Antoni","family":"Rosell","sequence":"additional","affiliation":[{"name":"Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona , , ,","place":["Badalona, Barcelona, Spain, 08916"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-0791","authenticated-orcid":true,"given":"Robert","family":"Texid\u00f3","sequence":"additional","affiliation":[{"name":"Institut Qu\u00edmic de Sarri\u00e0 (IQS), Universitat Ramon Llull , , Via Augusta 390 ,","place":["Barcelona, Spain, 08017"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026092100084434500_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microb.2025.100436","article-title":"A Comprehensive Review on Biofilm-Associated Infections: Mechanisms, Diagnostic Challenges, and Innovative Therapeutic Strategies","volume":"8","author":"Grari","year":"2025","journal-title":"Microbe"},{"key":"2026092100084434500_cit2","doi-asserted-by":"publisher","first-page":"5061","DOI":"10.2147\/IDR.S379502","article-title":"Biofilm-Associated Multi-Drug Resistance in Hospital-Acquired Infections: A Review","volume":"15","author":"Assefa","year":"2022","journal-title":"Infect. 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