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However, the development of functionalization techniques for isolated extracellular vesicles\u2014including improving their intracellular uptake efficacy from the perspective of a drug delivery system and targeting disease-associated cells to reduce side effects\u2014has become an urgent priority. The aim of this study was to develop a technology for modifying the surface of exosome membranes with functional molecules using membrane-curvature-sensing peptides. By using a cassette-based approach to modify the surface of exosomes with functional peptides that induce macropinocytosis, this technology achieved highly efficient intracellular delivery of exosomes. Furthermore, we applied this technology to boron neutron capture therapy (BNCT). By encapsulating therapeutic boron agents within exosomes, effective induction of cancer cell death through thermal neutron irradiation in BNCT was achieved.<\/jats:p>","DOI":"10.1021\/acsabm.6c00698","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:01:58Z","timestamp":1790190118000},"page":"9035-9046","source":"Crossref","is-referenced-by-count":1,"title":["Modification Technology for Exosome Membranes using Membrane-Curvature-Sensing Peptides and Its Application to Boron Neutron Capture Therapy"],"prefix":"10.1021","volume":"9","author":[{"given":"Miho","family":"Nakabo","sequence":"first","affiliation":[{"name":"Osaka Metropolitan University , , , ,","place":["Sakai, Osaka, Japan, 599-8531"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-2922","authenticated-orcid":true,"given":"Kenichi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Hiroshima University , , 1-2-3 Kasumi, 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