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Here, we report a mussel-inspired, dopamine-grafted curdlan hydrogel (Cur-DA) featuring a predominantly single-helical \u03b2-glucan architecture. Cur-DA hydrogels were synthesized under alkaline conditions using ethylene glycol diglycidyl ether (EGDE) as a linker, thereby facilitating regioselective dopamine grafting at the C6 position of curdlan. Spectroscopic analyses (UV\u2013Vis, FTIR, solid-state 13C NMR, XRD, and circular dichroism), together with XPS characterization, confirmed successful dopamine incorporation and a conformational transition from native triple helices to more flexible single helices. With this single-helical architecture and catechol functionalization, Cur-DA formed a nanofibrous, porous network with high water content (&amp;gt;90%), increased swelling capacity, and excellent mechanical compliance. Owing to catechol-mediated interfacial interactions and the mobility of single-helical chains, which likely serve as dynamic \u201csticky ends,\u201d Cur-DA hydrogels exhibited robust tissue adhesion (up to 10.21 kPa), self-healing, and outstanding injectability. In vitro assays indicated excellent hemocompatibility and cytocompatibility. In a murine full-thickness skin wound model, an optimized formulation (Cur-DA3) accelerated wound closure, promoted re-epithelialization, and enhanced collagen deposition without inducing systemic toxicity. This work establishes a conformation-engineering strategy for \u03b2-glucan hydrogels and highlights Cur-DA as a promising injectable, adhesive wound dressing.<\/jats:p>","DOI":"10.1021\/acsabm.6c00819","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:01:11Z","timestamp":1786737671000},"page":"8100-8114","source":"Crossref","is-referenced-by-count":1,"title":["Single-Helical Dopamine-g-Curdlan Hydrogels Showing High Adhesiveness and Injectability"],"prefix":"10.1021","volume":"9","author":[{"given":"Dongxue","family":"Lu","sequence":"first","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Xu","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Guo","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-2865","authenticated-orcid":true,"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-3716","authenticated-orcid":true,"given":"Chaoxi","family":"Wu","sequence":"additional","affiliation":[{"name":"Jinan University , , Huang-Pu Avenue West 601 , ,","place":["Guangzhou, China, 510632"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"2026092215073841900_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115120","article-title":"Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment","volume":"203","author":"Monaghan","year":"2023","journal-title":"Adv. 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