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In this study, we developed a dual-crosslinked hyaluronic acid (HA)-based hydrogel dressing with a glucose-responsive ROS-scavenging behavior. The hydrogel was composed of methacrylated HA-phenylboronic acid (HAMA-PBA) and HA-dopamine (HA-DA), forming a stable primary network through photocrosslinking and a dynamic secondary network via reversible boronate\u2212catechol interactions. Under hyperglycemic conditions, the competitive binding of glucose to PBA modulates these dynamic interactions, enabling the glucose-responsive regulation of antioxidant activity. The resulting hydrogel exhibited mechanical properties suitable for wound dressing applications and showed good biocompatibility. Glucose-dependent ROS scavenging and enhanced keratinocyte migration were observed in vitro. In a mouse model of chronic diabetic wounds, hydrogel treatment was associated with accelerated wound closure accompanied by improved re-epithelialization and collagen organization compared with those in control groups. Overall, these findings indicated that glucose-responsive antioxidant modulation using HA-based hydrogels can be a useful approach for managing oxidative stress in chronic diabetic wounds.<\/jats:p>","DOI":"10.1021\/acsabm.6c00892","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:48:22Z","timestamp":1784094502000},"page":"7130-7142","source":"Crossref","is-referenced-by-count":1,"title":["Hyaluronic Acid-Based Hydrogel with a Glucose-Responsive ROS Scavenging Ability for Diabetic Wound Healing"],"prefix":"10.1021","volume":"9","author":[{"given":"Jin Young","family":"Hong","sequence":"first","affiliation":[{"name":"College of Engineering, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]},{"name":"Seoul National University , , ,","place":["Seoul, Republic of Korea, 03080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Engineering, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hee","family":"Min","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine , , ,","place":["Seoul, Republic of Korea, 03080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Seul","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine , , ,","place":["Seoul, Republic of Korea, 03080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Engineering, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]},{"name":"Seoul National University , , ,","place":["Seoul, Republic of Korea, 03080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine , , ,","place":["Seoul, Republic of Korea, 03080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngjae","family":"Chun","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-9377","authenticated-orcid":true,"given":"Young Bin","family":"Choy","sequence":"additional","affiliation":[{"name":"College of Engineering, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]},{"name":"Seoul National University , , ,","place":["Seoul, Republic of Korea, 03080"]},{"name":"Seoul National University College of Medicine , , ,","place":["Seoul, Republic of Korea, 03080"]},{"name":"Seoul National University , , ,","place":["Seoul, Republic of Korea, 03080"]},{"name":"Institute of Convergence Medicine with Innovative Technology, Seoul National University Hospital , ,","place":["Seoul, Republic of Korea, 03122"]},{"name":"ToBIOS Inc. , 6F, 214 Yulgok-ro, Jongro-gu , ,","place":["Seoul, Republic of Korea, 03122"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"11","key":"2026080308063925800_cit1","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/S2213-8587(23)00159-6","article-title":"Understanding diabetes heterogeneity: key steps towards precision medicine in diabetes","volume":"11","author":"Leslie","year":"2023","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"585","key":"2026080308063925800_cit2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe4839","article-title":"Advanced bandages for diabetic wound healing","volume":"13","author":"Matoori","year":"2021","journal-title":"Sci. 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