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Although conductive nanomaterials such as graphene oxide\u2013silver nanoparticles (GO\u2013AgNPs) have shown promise in promoting neurite outgrowth and neuronal maturation, their application is limited by structural instability and burst silver ion (Ag+) release under oxidative conditions. Here, we introduce a carbon dot (CD)-enabled strategy to stabilize conductive GO\u2013Ag nanocomposites via green, in situ integration of folic acid-derived nitrogen-doped CDs. This design transforms conventional GO\u2013AgNPs into a redox-active, self-regulating conductive platform, GO-CD\u2013AgNPs (GC\u2013AgNPs), that simultaneously enhances electrical stability and mitigates oxidative damage. GC\u2013AgNPs exhibit sustained electrical conductivity under oxidative stress and markedly enhanced radical scavenging capacity. In SH-SY5Y cells, GC\u2013AgNPs significantly reduce cytotoxicity by preventing superoxide overproduction and intracellular Ca2+ overload. Under oxidative stress, these nanocomposites promote neuronal maturation, as evidenced by increased expression of MAP2 and NF-H. In addition, GC\u2013AgNPs suppress pro-inflammatory cytokine secretion in HMC3 microglia, demonstrating concurrent immunomodulatory effects. Collectively, by resolving the intrinsic coupling between conductivity and oxidative stability, this work establishes a design framework for redox-adaptive conductive biomaterials. This strategy provides a promising approach for designing electroactive biomaterials capable of maintaining neural network integrity in challenging pathological microenvironments.<\/jats:p>","DOI":"10.1021\/acsabm.6c00934","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:01:39Z","timestamp":1788818499000},"page":"8580-8592","source":"Crossref","is-referenced-by-count":0,"title":["Carbon Dot-Engineered Graphene Oxide\u2013Silver Nanoparticle Nanocomposites Orchestrate Conductivity\u2013Redox Coupling for Neuronal Regeneration"],"prefix":"10.1021","volume":"9","author":[{"given":"Ya-Ping","family":"Shiau","sequence":"first","affiliation":[{"name":"University of California Davis , , , ,","place":["Sacramento, California, United States, 95817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7495-8823","authenticated-orcid":true,"given":"Jay Ming","family":"Tong","sequence":"additional","affiliation":[{"name":"University of California Davis , , , ,","place":["Sacramento, California, United States, 95817"]},{"name":"University of California Davis , , , ,","place":["Davis, California, United States, 95616"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Shi","sequence":"additional","affiliation":[{"name":"University of California Davis , , , ,","place":["Sacramento, California, United States, 95817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzheng","family":"Guo","sequence":"additional","affiliation":[{"name":"University of California Davis , , , ,","place":["Sacramento, California, United States, 95817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nolta","sequence":"additional","affiliation":[{"name":"University of California Davis Medical Center , , , ,","place":["Sacramento, California, United States, 95817"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-7344","authenticated-orcid":true,"given":"Dake","family":"Hao","sequence":"additional","affiliation":[{"name":"University of California Davis , , , ,","place":["Sacramento, California, United States, 95817"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2026092100082936000_cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00439","article-title":"Structural homeostasis in the nervous system: a balancing act for wiring plasticity and stability","volume":"8","author":"Yin","year":"2014","journal-title":"Front. 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