{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:02:35Z","timestamp":1790107355560,"version":"4.0.1"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020YQ15"],"award-info":[{"award-number":["ZR2020YQ15"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The therapeutic efficacy of chemodynamic therapy (CDT) is severely constrained by insufficient endogenous hydrogen peroxide (H2O2), excessive glutathione (GSH)-mediated scavenging of hydroxyl radicals (\u00b7OH), and the limited abundance of lipid peroxidation (LPO) substrates due to low membrane unsaturation in tumor cells. To address these challenges, we herein develop a tumor microenvironment (TME)-responsive, multifunctional mesoporous multimetallic nanozyme (CuPtAu, CPA) loaded with the lipid metabolism modulator oleanolic acid (OA) and further coated with hyaluronic acid (HA), constructing a targeted nanoplatform (CPA\/OA@HA). This system achieves tumor-specific enrichment via HA-mediated CD44 targeting and responsively releases OA within the TME, which significantly increasing the proportion of polyunsaturated fatty acids (PUFAs), thereby providing abundant substrates for LPO. Concurrently, the CPA nanozyme exhibits intrinsic glucose oxidase (GOx)-, catalase (CAT)-, and peroxidase (POD)-mimicking activities, enabling self-supply of H2O2 and O2, sustained generation of \u00b7OH, and efficient depletion of GSH. Through a dual synergistic strategy of substrate enhancement and catalytic amplification, CPA\/OA@HA potently propagates the LPO chain reaction, inducing irreversible oxidative damage to tumor cells. Both in vitro and in vivo results demonstrate remarkable tumor suppression at low doses with excellent biocompatibility. This metabolic intervention-integrated CDT strategy provides a paradigm to overcome oxidative resistance in cancer therapy.<\/jats:p>","DOI":"10.1021\/acsabm.6c00946","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:01:45Z","timestamp":1786960905000},"page":"8150-8157","source":"Crossref","is-referenced-by-count":0,"title":["Amplifying Lipid Peroxidation via a Cascade Nanozyme with Lipid Metabolism Reprogramming for Enhanced Chemodynamic Therapy"],"prefix":"10.1021","volume":"9","author":[{"given":"Yuhang","family":"Wang","sequence":"first","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, P. R. China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, P. R. China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, P. R. China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8382","authenticated-orcid":true,"given":"Zhengze","family":"Yu","sequence":"additional","affiliation":[{"name":"Qingdao University , , , ,","place":["Qingdao, Shandong, P. R. China, 266071"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026092215063493400_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309261","article-title":"Rapid synthesis of trimetallic nanozyme for sustainable cascaded catalytic therapy via tumor microenvironment remodulation","volume":"36","author":"Jia","year":"2024","journal-title":"Adv. Mater."},{"key":"2026092215063493400_cit2","doi-asserted-by":"publisher","first-page":"20402","DOI":"10.1021\/acsnano.3c06833","article-title":"Design and mechanism insight of monodispersed AuCuPt alloy nanozyme with antitumor activity","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"2026092215063493400_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308033","article-title":"nanozyme composite for augmented cascade catalytic tumor therapy","volume":"36","author":"Cheng","year":"2024","journal-title":"Adv. Mater."},{"key":"2026092215063493400_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202520859","article-title":"Atomic-Precision Triple-Enzyme Nanozyme Synchronizes Mitochondrial Dual-Pathway Disruption for Precision Oncology","volume":"65","author":"Zhang","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092215063493400_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003563","article-title":"Immunomodulation-enhanced nanozyme-based tumor catalytic therapy","volume":"32","author":"Xu","year":"2020","journal-title":"Adv. Mater."},{"key":"2026092215063493400_cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202208513","article-title":"Genetically engineered protein corona-based cascade nanozymes for enhanced tumor therapy","volume":"32","author":"Liu","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"2026092215063493400_cit7","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1002\/anie.202008868","article-title":"Self-assembled single-site nanozyme for tumor-specific amplified cascade enzymatic therapy","volume":"133","author":"Wang","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092215063493400_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202332","article-title":"A noble AuPtAg-GOx nanozyme for synergistic tumor immunotherapy induced by starvation therapy-augmented mild photothermal therapy","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci."},{"key":"2026092215063493400_cit9","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1021\/acsnano.5c17672","article-title":"Self-Propelled Nanoreactors for Enhanced Cascade Catalytic Cancer Therapy through NIR-II Fluorescence Imaging-Guided Readministration","volume":"20","author":"Wang","year":"2026","journal-title":"ACS Nano"},{"key":"2026092215063493400_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202405321","article-title":"All-in-One\u201d MnO2@PtAuRu Nanoreactor for Self-Replenishing and Cascade Catalytic Therapy of Cancer","volume":"20","author":"Li","year":"2024","journal-title":"Small"},{"key":"2026092215063493400_cit11","doi-asserted-by":"publisher","first-page":"41368","DOI":"10.1021\/acsnano.5c16515","article-title":"Self-Assembled Spatially Confined Mo-Based Nanoreactor for Multimechanistic Tumor Therapy Driven by Self-Cascade Catalysis","volume":"19","author":"Sun","year":"2025","journal-title":"ACS Nano"},{"key":"2026092215063493400_cit12","doi-asserted-by":"publisher","first-page":"22153","DOI":"10.1021\/acsnano.4c05483","article-title":"Hypoxia reversion and STING pathway activation through large mesoporous nanozyme for near-infrared-II light amplified tumor polymetallic-immunotherapy","volume":"18","author":"Qu","year":"2024","journal-title":"ACS Nano"},{"key":"2026092215063493400_cit13","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03856-3","article-title":"Mesoporous multimetallic PdPtBi nanozymes target redox imbalance and glutamine deprivation for immuno-chemodynamic therapy","volume":"23","author":"Qiu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"2026092215063493400_cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2025.138871","article-title":"Multi-metal nanozyme loaded (Zr\/Ce) UiO-66 driven self-cascade catalysis nanoreactor based on split aptamer for sensitive detection of pathogenic bacteria","volume":"447","author":"Song","year":"2025","journal-title":"Sens. Actuators, B"},{"key":"2026092215063493400_cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147161","article-title":"A large-pore mesoporous Au@Pt@Rh trimetallic nanostructure with hyperthermia-enhanced enzyme-mimic activities for immunomodulation-improved tumor catalytic therapy","volume":"477","author":"Song","year":"2023","journal-title":"Chem. Eng. J."},{"key":"2026092215063493400_cit16","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1007\/s40843-024-3300-6","article-title":"One-step synthesis of PtRhMo\/Rh nanozymes for mitochondrial damage-mediated photothermal\/enzymatic therapy","volume":"68","author":"Li","year":"2025","journal-title":"Sci. China Mater."},{"key":"2026092215063493400_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202415778","article-title":"ZnO-CuS\/F127 Hydrogels with Multienzyme Properties for Implant-Related Infection Therapy by Inhibiting Bacterial Arginine Biosynthesis and Promoting Tissue Repair","volume":"35","author":"Sun","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"2026092215063493400_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140811","article-title":"A photo-modulated organometallic nanozyme based on \u03b2-cyclodextrin-capped gold nanoparticles for the detection of Zn (II) and cascade catalysis","volume":"455","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"2026092215063493400_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158504","article-title":"Efficient bimetallic nanozyme precisely tuned by DNA for high-throughput foldable paper biosensing","volume":"503","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026092215063493400_cit20","doi-asserted-by":"publisher","first-page":"30716","DOI":"10.1021\/acsami.5c05324","article-title":"Dendrimer-entrapped CuPt bimetallic nanozymes for tumor microenvironment-regulated photothermal\/catalytic therapy","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026092215063493400_cit21","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202218407","article-title":"Amplification of lipid peroxidation by regulating cell membrane unsaturation to enhance chemodynamic therapy","volume":"62","author":"Zhu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092215063493400_cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401893","article-title":"Peroxidase-Mimicking Iron-Based Single-Atom Upconversion Photocatalyst for Enhancing Chemodynamic Therapy","volume":"34","author":"Le","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"2026092215063493400_cit23","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00380-z","article-title":"Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo\/PDT\/CDT","volume":"27","author":"Fu","year":"2023","journal-title":"Biomater. Res."},{"key":"2026092215063493400_cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309711","article-title":"Lipid droplet targeting type I photosensitizer for ferroptosis via lipid peroxidation accumulation","volume":"36","author":"Xiong","year":"2024","journal-title":"Adv. Mater."},{"key":"2026092215063493400_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202419120","article-title":"Fe\/Mo-Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti-Breast Cancer Immunity","volume":"37","author":"Xiang","year":"2025","journal-title":"Adv. Mater."},{"key":"2026092215063493400_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212510","article-title":"A self-enhancing nanoreactor reinforces radioimmunotherapy by reprogramming nutrients and redox metabolisms","volume":"33","author":"Hou","year":"2023","journal-title":"Adv. Funct. Mater."}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c00946","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/17\/8150\/66609066\/mt-2026-00946n.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/9\/17\/8150\/66609066\/mt-2026-00946n.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:13:47Z","timestamp":1790104427000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/9\/17\/8150\/5259585\/Amplifying-Lipid-Peroxidation-via-a-Cascade"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":26,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,8,17]]},"published-print":{"date-parts":[[2026,9,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c00946","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}