{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:43:52Z","timestamp":1792399432937,"version":"4.4.0"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"20","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nanoscale graphene oxide (nGO) has emerged as a promising biomaterial for neurological applications because its ultrasmall dimensions, oxygen-containing surface chemistry, and colloidal behavior may support biologically relevant interfacial interactions. Here, we physicochemically defined nGO synthesized by a modified Taylor\u2013Couette method using transmission electron microscopy, atomic force microscopy, particle size analysis, zeta potential measurement, X-ray diffraction, and Fourier-transform infrared spectroscopy. The resulting nGO exhibited ultrasmall lateral dimensions together with characteristic oxygen-containing functional groups and a negative zeta potential in distilled water. In a time-course dot blot assay using \u03b1-synuclein (\u03b1-syn) preformed fibrils, incubation with nGO was associated with reduced fibril-related \u03b1-syn immunoreactivity without a statistically significant change in total \u03b1-syn signal; a fractionation assay further revealed fraction-dependent differences in antibody-detectable \u03b1-syn signals. We then evaluated behavioral and nigral histological outcomes following intraperitoneal nGO administration in a rat model of Parkinson\u2019s disease induced by unilateral adeno-associated virus-mediated overexpression of A53T \u03b1-syn in the substantia nigra. nGO administration was associated with improved stepping performance, greater preservation of nigral tyrosine hydroxylase-positive cells, reduced nigral \u03b1-syn immunoreactivity, and decreased Iba-1-positive area. Collectively, these findings support further consideration of physicochemically defined, unmodified nGO as an active biomaterial associated with fibril-related \u03b1-syn readouts in vitro and functional and histological outcomes consistent with neuroprotection in vivo.<\/jats:p>","DOI":"10.1021\/acsabm.6c00968","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:02:07Z","timestamp":1790647327000},"page":"9582-9592","source":"Crossref","is-referenced-by-count":0,"title":["Physicochemically Defined Nanoscale Graphene Oxide Modulates Fibril-Related \u03b1-Synuclein and Attenuates Parkinsonian Pathology In Vivo"],"prefix":"10.1021","volume":"9","author":[{"given":"Sung-Ae","family":"Cha","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Asan Medical Center, University of Ulsan College of Medicine , , ,","place":["Seoul, Korea, 05505"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Kwang","family":"Seo","sequence":"additional","affiliation":[{"name":"Asan Medical Center, University of Ulsan College of Medicine , , ,","place":["Seoul, Korea, 05505"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Institute of Convergence Technology, INBCT Co., LTD , ,","place":["Hwaseong, Republic of Korea, 18462"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaechul","family":"Ryu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]},{"name":"Institute of Convergence Technology, INBCT Co., LTD , ,","place":["Hwaseong, Republic of Korea, 18462"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-741X","authenticated-orcid":true,"given":"Kyung-Sun","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Seoul National University , , ,","place":["Seoul, Republic of Korea, 08826"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ryong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Asan Medical Center, University of Ulsan College of Medicine , , ,","place":["Seoul, Korea, 05505"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026101904072834600_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40820-019-0237-5","article-title":"Comprehensive Application of Graphene: Emphasis on Biomedical Concerns","volume":"11","author":"Syama","year":"2019","journal-title":"Nano Micro Lett."},{"key":"2026101904072834600_cit2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jconrel.2022.08.011","article-title":"Multifunctional Graphene Oxide Nanoparticles for Drug Delivery in Cancer","volume":"350","author":"Itoo","year":"2022","journal-title":"J. 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