{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:30:52Z","timestamp":1786966252536,"version":"build-2736575974"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2221-E-027-038-MY3"],"award-info":[{"award-number":["NSTC 112-2221-E-027-038-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2321-B-A49-008"],"award-info":[{"award-number":["NSTC 112-2321-B-A49-008"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-182A-128"],"award-info":[{"award-number":["NSTC 113-2314-B-182A-128"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is a major neurodegenerative disorder associated with amyloid-\u03b2 (A\u03b2) aggregation and oxidative stress, often linked to metal ion dyshomeostasis. In this study, we developed a clioquinol (CQ)-loaded UiO-66(Ce), a cerium-based metal-organic framework (MOF), as a potential dual-functional platform. The system is designed to combine reactive oxygen species (ROS) scavenging via Ce(III)\/Ce(IV) redox cycling with the metal-chelating capability of CQ, aiming to modulate multiple AD-related pathological factors. The material was synthesized and characterized, and its biological performance was preliminarily evaluated in PC-12 cells using an A\u03b2-Cu2+ model system. The results suggest that UiO-66(Ce)-CQ exhibits acceptable biocompatibility and is associated with reduced intracellular ROS levels, improved cell viability, and modulation of A\u03b2 aggregation behavior. Compared with its individual components, UiO-66(Ce)-CQ showed enhanced overall performance under the tested conditions. While this study is limited to initial in vitro evaluation, the findings provide a preliminary proof of concept for integrating ROS-scavenging and metal-chelating functionalities within a single MOF-based platform, which may offer a potential strategy for AD-related applications.<\/jats:p>","DOI":"10.1021\/acsabm.6c01023","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:18:46Z","timestamp":1785849526000},"page":"7629-7636","source":"Crossref","is-referenced-by-count":0,"title":["Clioquinol-Loaded UiO-66(Ce) Metal-Organic Frameworks for Dual Reactive Oxygen Species Scavenging and Metal Chelation in Alzheimer\u2019s Disease"],"prefix":"10.1021","volume":"9","author":[{"given":"Lenin","family":"Subramanian","sequence":"first","affiliation":[{"name":"National Taipei University of Technology (Taipei Tech) , , ,","place":["Taipei, Taiwan, 10608"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yung","family":"Wu","sequence":"additional","affiliation":[{"name":"National Taipei University of Technology (Taipei Tech) , , ,","place":["Taipei, Taiwan, 10608"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Zhe","family":"Bai","sequence":"additional","affiliation":[{"name":"National Taipei University of Technology (Taipei Tech) , , ,","place":["Taipei, Taiwan, 10608"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-439X","authenticated-orcid":true,"given":"Yu-Chien","family":"Lin","sequence":"additional","affiliation":[{"name":"Nanyang Technological University , , 50 Nanyang Avenue , ,","place":["Singapore, Singapore, 639798"]},{"name":"BIOBOND LTD , , ,","place":["Corsham, Wiltshire, United Kingdom, SN13 0B"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.-W.","family":"Wu","sequence":"additional","affiliation":[{"name":"National Taiwan University , , ,","place":["Taipei, Taiwan, 106216"]},{"name":"Yuan Ze University , , Chung-Li , ,","place":["Taoyuan, Taiwan, 320315"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-3680","authenticated-orcid":true,"given":"Ren-Jei","family":"Chung","sequence":"additional","affiliation":[{"name":"National Taipei University of Technology (Taipei Tech) , , ,","place":["Taipei, Taiwan, 10608"]},{"name":"National Taipei University of Technology (Taipei Tech) , , ,","place":["Taipei, Taiwan, 10608"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026081707161407800_cit1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.clinbiochem.2019.04.015","article-title":"Clinical aspects of Alzheimer's disease","volume":"72","author":"Zv\u011b\u0159ov\u00e1","year":"2019","journal-title":"Clin. 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