{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:47:47Z","timestamp":1792399667540,"version":"4.4.0"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"20","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Agency for Support and Evaluation of Graduate Education (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bioactive wound dressings that combine structural support with local biological activity are promising for skin repair. Nile tilapia skin peptides (NTSP) have demonstrated wound-healing potential, while chitosan (CS) offers favorable film-forming, biodegradable, and wound-contact properties. Combining these components may provide a structured platform for topical application of bioactive peptides. This study investigated incorporating NTSP into CS membranes and its effects on physicochemical performance and wound healing. CS membranes containing NTSP at 600 or 1000 \u03bcg\/mL were characterized and evaluated in a full-thickness wound model in Wistar rats; peptide-free and bovine skin peptide-loaded CS membranes served as comparators. FTIR and XRD supported NTSP incorporation through predominantly noncovalent interactions, without forming a separate crystalline phase. NTSP significantly reduced water vapor permeability from 2.80 \u00b1 0.22 g.mm.m\u20132.day\u20131.kPa\u20131 in control membranes to 1.78 \u00b1 0.16 and 1.63 \u00b1 0.24 g.mm.m\u20132.day\u20131.kPa\u20131 at 600 and 1000 \u03bcg\/mL, respectively (p &amp;lt; 0.05). The 600 \u03bcg\/mL membrane showed the highest swelling in simulated exudate fluid (2250.39 \u00b1 64.98% at 24 h; p &amp;lt; 0.0001 vs control), whereas all formulations underwent progressive lysozyme-mediated degradation. Tensile strength decreased with peptide loading, with a significant difference between control and 1000 \u03bcg\/mL membranes (p = 0.0181). On day 7, wound contraction reached 45.56 \u00b1 8.22% and 55.73 \u00b1 15.39% for the 600 and 1000 \u03bcg\/mL membranes, compared with 36.60 \u00b1 3.36% for peptide-free CS and 9.97 \u00b1 2.98% for the bovine-peptide comparator. At day 14, the 600 \u03bcg\/mL formulation remained superior to the 1000 \u03bcg\/mL and bovine-peptide groups (p = 0.0157 and p = 0.0016). Histological and immunohistochemical findings showed temporal changes in inflammatory-cell recruitment, angiogenesis, fibroblast accumulation, matrix deposition, and TNF-\u03b1 and IL-6 expression. Overall, the 600 \u03bcg\/mL NTSP-loaded CS membrane provided the most favorable balance between material performance and biological response, supporting its development as a structured bioactive wound dressing.<\/jats:p>","DOI":"10.1021\/acsabm.6c01087","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:01:38Z","timestamp":1791374498000},"page":"9628-9642","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Chitosan Membranes Loaded with Nile Tilapia Skin Peptides Promote Wound Healing Associated with Temporal Inflammatory Modulation"],"prefix":"10.1021","volume":"9","author":[{"given":"Rodrigo","family":"Tozetto","sequence":"first","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia B.","family":"de Macedo","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina T.","family":"Ventura","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Cl\u00e1udia M. O.","family":"Capote","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Let\u00edcia","family":"M. da Silva","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata K.","family":"Crizante","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi M.","family":"Tozetto","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan J.","family":"Baldissera","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5120-021X","authenticated-orcid":true,"given":"Pedro Henrique G.","family":"Salvador","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Y.","family":"Koga","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro C.","family":"Lipinski","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9velin L.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"State University of Maring\u00e1 , , Avenue, 5790 , , ,","place":["Colombo, Parana, Brazil, 87020-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo C.","family":"Meurer","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1 , , Dr. Jo\u00e3o Max\u00edmiano Street, 426 , ,","place":["Parana, Brazil, 86900-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7067-5802","authenticated-orcid":true,"given":"Fl\u00e1vio L.","family":"Beltrame","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-6646","authenticated-orcid":true,"given":"Priscileila C.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"State University of Ponta Grossa , , General Carlos Cavalcanti Avenue, 4748 , ,","place":["Parana, Brazil, 84900-030"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"2026101904074534700_cit1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.lwt.2015.10.070","article-title":"Extraction and Characterization of Acid-Soluble Collagen from Scales and Skin of Tilapia (Oreochromis Niloticus)","volume":"66","author":"Chen","year":"2016","journal-title":"LWT - Food Sci. Technol."},{"key":"2026101904074534700_cit2","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1016\/j.ijbiomac.2020.08.109","article-title":"Research Status of Self-Healing Hydrogel for Wound Management: A Review","volume":"164","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026101904074534700_cit3","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduction Targeted Ther."},{"issue":"16","key":"2026101904074534700_cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163890","article-title":"Sponges of Carboxymethyl Chitosan Grafted with Collagen Peptides for Wound Healing","volume":"20","author":"Cheng","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026101904074534700_cit5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/139476","article-title":"Biocompatibility of Novel Type I Collagen Purified from Tilapia Fish Scale: An In Vitro Comparative Study","volume":"2015","author":"Tang","year":"2015","journal-title":"Biomed Res. Int."},{"issue":"2","key":"2026101904074534700_cit6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1089\/wound.2022.0142","article-title":"A Systematic Review of Fish-Based Biomaterial on Wound Healing and Anti-Inflammatory Processes","volume":"13","author":"Gomathy","year":"2024","journal-title":"Adv. Wound Care"},{"issue":"6","key":"2026101904074534700_cit7","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1021\/acs.jafc.9b08002","article-title":"Collagen Peptides Isolated from Salmo Salar and Tilapia Nilotica Skin Accelerate Wound Healing by Altering Cutaneous Microbiome Colonization via Upregulated NOD2 and BD14","volume":"68","author":"Mei","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"2026101904074534700_cit8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1021\/acsbiomaterials.5c01219","article-title":"Evaluation of Nile Tilapia (Oreochromis Niloticus) Skin Peptides for Wound Healing: A Systematic and Meta-Analysis Review","volume":"12","author":"Tozetto","year":"2026","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"11","key":"2026101904074534700_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300863","article-title":"Study of the Antioxidant, Antimicrobial, and Wound Healing Properties of Raw Hydrolyzed Extract from Nile Tilapia Skin (Oreochromis Niloticus)","volume":"20","author":"Tozetto","year":"2023","journal-title":"Chem. Biodivers."},{"issue":"5","key":"2026101904074534700_cit10","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/01.ASW.0000723128.58588.b5","article-title":"The Effect of Chitosan in Wound Healing: A Systematic Review","volume":"34","author":"Liu","year":"2021","journal-title":"Adv Skin Wound Care"},{"issue":"27","key":"2026101904074534700_cit11","doi-asserted-by":"publisher","first-page":"19219","DOI":"10.1039\/d4ra01594k","article-title":"Chitosan Alchemy: Transforming Tissue Engineering and Wound Healing","volume":"14","author":"Pramanik","year":"2024","journal-title":"RSC Adv."},{"key":"2026101904074534700_cit12","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ijbiomac.2021.03.085","article-title":"Preparation of Nano-Hydroxyapatite\/Chitosan\/Tilapia Skin Peptides Hydrogels and Its Burn Wound Treatment","volume":"181","author":"Qianqian","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"2026101904074534700_cit13","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1016\/j.ijbiomac.2020.09.006","article-title":"Marine Collagen Peptide Grafted Carboxymethyl Chitosan: Optimization Preparation and Coagulation Evaluation","volume":"164","author":"Cheng","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026101904074534700_cit14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.anifeedsci.2014.06.010","article-title":"Utilization of Tilapia Processing Waste for the Production of Fish Protein Hydrolysate","volume":"196","author":"Silva","year":"2014","journal-title":"Anim. Feed Sci. Technol."},{"issue":"2","key":"2026101904074534700_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/jfb16020045","article-title":"Recent Advancements in Chitosan-Based Biomaterials for Wound Healing","volume":"16","author":"Shah","year":"2025","journal-title":"J. Funct. Biomater."},{"key":"2026101904074534700_cit16","first-page":"1","volume-title":"Designaci\u00f3n D 882: \u201cStandard Test Method for Tensile Properties of Thin Plastic Sheeting\u201d","author":"American Society for Testing and Materials","year":"2002"},{"key":"2026101904074534700_cit17","first-page":"1","article-title":"Standard Test Methods for Water Vapor Transmission of Materials, E 96\/E 96M - 05","volume":"i","author":"ASTM E 96","year":"1995","journal-title":"ASTM"},{"key":"2026101904074534700_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214337","article-title":"Alginate-Based Hydrogels for Sustained Antimicrobial Peptide Delivery to Enhance Wound Healing in Diabetes","volume":"175","author":"Da Silva","year":"2025","journal-title":"Biomater. Adv."},{"key":"2026101904074534700_cit19","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.ijbiomac.2022.11.100","article-title":"Preparation and Evaluation of Chitosan- and Hyaluronic Acid-Grafted Pullulan Succinate Films for Skin Wound Healing","volume":"223","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"1\u20132","key":"2026101904074534700_cit20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijpharm.2007.03.042","article-title":"Evaluation of Semi-Interpenetrating Polymer Networks Composed of Chitosan and Poloxamer for Wound Dressing Application","volume":"341","author":"Kim","year":"2007","journal-title":"Int. J. Pharm."},{"issue":"8","key":"2026101904074534700_cit21","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound Healing Dressings and Drug Delivery Systems: A Review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"2026101904074534700_cit22","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/J.BIOTECHADV.2011.01.005","article-title":"Biomaterials Based on Chitin and Chitosan in Wound Dressing Applications","volume":"29","author":"Jayakumar","year":"2011","journal-title":"Biotechnol. Adv."},{"issue":"7","key":"2026101904074534700_cit23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s10965-022-03121-3","article-title":"Recent Advances of Chitosan-Based Polymers in Biomedical Applications and Environmental Protection","volume":"29","author":"Fatullayeva","year":"2022","journal-title":"J. Polym. Res."},{"issue":"2","key":"2026101904074534700_cit24","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s11694-023-02265-0","article-title":"Contribution of Amino Acid Composition and Secondary Structure to the Antioxidant Properties of Tilapia Skin Peptides","volume":"18","author":"Ma","year":"2024","journal-title":"J. Food Meas. Charact."},{"issue":"1","key":"2026101904074534700_cit25","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2025.2603716","article-title":"Novel Antioxidant Peptide from Tilapia Skin: Identification and Structure Elucidation","volume":"29","author":"Fu","year":"2026","journal-title":"Int. J. Food Prop."},{"issue":"4","key":"2026101904074534700_cit26","doi-asserted-by":"publisher","DOI":"10.3390\/polym15040841","article-title":"Development of Hybrid Materials Based on Chitosan, Poly(Ethylene Glycol) and Laponite\u00ae RD: Effect of Clay Concentration","volume":"15","author":"Morariu","year":"2023","journal-title":"Polymers"},{"key":"2026101904074534700_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129304","article-title":"Tuning Glycerol Plasticization of Chitosan with Boric Acid","volume":"258","author":"Scott","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"2026101904074534700_cit28","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1021\/bm200193u","article-title":"Interplay between Structure and Dynamics in Chitosan Films Investigated with Solid-State NMR, Dynamic Mechanical Analysis, and X-Ray Diffraction","volume":"12","author":"Gartner","year":"2011","journal-title":"Biomacromolecules"},{"issue":"13","key":"2026101904074534700_cit29","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1021\/ma8021234","article-title":"Understanding of the Plasticizing Effects of Glycerol and PEG 400 on Chitosan Films Using Solid-State NMR Spectroscopy","volume":"42","author":"Domj\u00e1n","year":"2009","journal-title":"Macromolecules"},{"key":"2026101904074534700_cit30","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ijbiomac.2019.05.158","article-title":"Structural Characterization and Properties of Polyols Plasticized Chitosan Films","volume":"135","author":"Ma","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"2026101904074534700_cit31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s10856-022-06643-w","article-title":"Chitosan-Collagen-Hydroxyapatite Membranes for Tissue Engineering","volume":"33","author":"Becerra","year":"2022","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"7","key":"2026101904074534700_cit32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.progpolymsci.2006.06.001","article-title":"Chitin and Chitosan: Properties and Applications","volume":"31","author":"Rinaudo","year":"2006","journal-title":"Prog. Polym. Sci."},{"issue":"2","key":"2026101904074534700_cit33","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ijpharm.2013.12.015","article-title":"Natural and Synthetic Polymers for Wounds and Burns Dressing","volume":"463","author":"Mogo\u015fanu","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"8","key":"2026101904074534700_cit34","doi-asserted-by":"publisher","DOI":"10.3390\/biom10081169","article-title":"Advanced Hydrogels as Wound Dressings","volume":"10","author":"Tavakoli","year":"2020","journal-title":"Biomolecules"},{"key":"2026101904074534700_cit35","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.colsurfb.2016.03.052","article-title":"Electrospun Tilapia Collagen Nanofibers Accelerating Wound Healing via Inducing Keratinocytes Proliferation and Differentiation","volume":"143","author":"Zhou","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"28","key":"2026101904074534700_cit36","doi-asserted-by":"publisher","first-page":"40258","DOI":"10.1021\/acsami.5c08728","article-title":"PH-Responsive Bilayer Hydrogel with Synergistic Antibacterial\/Anti-Inflammatory Effect for Infected Wound Healing","volume":"17","author":"Huangfu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026101904074534700_cit37","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.3390\/md13041819","article-title":"Stability of Chitosan\u2014A Challenge for Pharmaceutical and Biomedical Applications","volume":"13","author":"Szyma\u0144ska","year":"2015","journal-title":"Mar. Drugs"},{"issue":"11","key":"2026101904074534700_cit38","doi-asserted-by":"publisher","first-page":"5532","DOI":"10.1021\/acs.molpharmaceut.3c00415","article-title":"Fabrication of Chitosan\/PEGDA Bionanocomposites for Enhanced Drug Encapsulation and Release Efficiency","volume":"20","author":"de Castro","year":"2023","journal-title":"Mol. Pharm."},{"issue":"3","key":"2026101904074534700_cit39","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/sj.jid.5700613","article-title":"Formation and Function of the Myofibroblast during Tissue Repair","volume":"127","author":"Hinz","year":"2007","journal-title":"J. Investig. Dermatol."},{"issue":"15","key":"2026101904074534700_cit40","doi-asserted-by":"publisher","DOI":"10.3390\/ma16155459","article-title":"Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing","volume":"16","author":"Xu","year":"2023","journal-title":"Materials"},{"issue":"1","key":"2026101904074534700_cit41","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2530693","article-title":"Marine Bioactive Peptides as Potential Therapeutic Agents for Wound Healing \u2013 a Review","volume":"57","author":"Zheng","year":"2025","journal-title":"Ann. Med."},{"issue":"3","key":"2026101904074534700_cit42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors Affecting Wound Healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"issue":"7","key":"2026101904074534700_cit43","doi-asserted-by":"publisher","first-page":"7093","DOI":"10.1016\/j.actbio.2013.03.033","article-title":"Recent Advances on the Development of Wound Dressings for Diabetic Foot Ulcer Treatment\u2014A Review","volume":"9","author":"Moura","year":"2013","journal-title":"Acta Biomater."},{"key":"2026101904074534700_cit44","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential Delivery of Immunomodulatory Cytokines to Facilitate the M1-to-M2 Transition of Macrophages and Enhance Vascularization of Bone Scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"key":"2026101904074534700_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2024.e02245","article-title":"Utilizing Tilapia Fish Skin Biomaterial for Burn Wound Dressing: A Systematic Review","volume":"24","author":"Zimba","year":"2024","journal-title":"Sci. Afr."},{"issue":"1","key":"2026101904074534700_cit46","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1046\/j.1087-0024.2000.00014.x","article-title":"Angiogenesis in Wound Healing","volume":"5","author":"Tonnesen","year":"2000","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"issue":"5","key":"2026101904074534700_cit47","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and Mechano-Regulation of Connective Tissue Remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"2026101904074534700_cit48","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth Factors and Cytokines in Wound Healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"issue":"15","key":"2026101904074534700_cit49","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1096\/fj.00-0073com","article-title":"Impaired Cutaneous Wound Healing in Interleukin-6-deficient and Immunosuppressed Mice","volume":"14","author":"Gallucci","year":"2000","journal-title":"FASEB J."},{"issue":"6","key":"2026101904074534700_cit50","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1189\/jlb.0802397","article-title":"Essential Involvement of IL-6 in the Skin Wound-Healing Process as Evidenced by Delayed Wound Healing in IL-6-Deficient Mice","volume":"73","author":"Lin","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"2026101904074534700_cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107100","article-title":"Novel Nano-Drug Delivery System for Natural Products and Their Application","volume":"201","author":"Huang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"2026101904074534700_cit52","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.addr.2017.05.010","article-title":"Macrophage-Based Therapeutic Strategies in Regenerative Medicine","volume":"122","author":"Spiller","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"2026101904074534700_cit53","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1098\/rsob.200223","article-title":"Wound Healing: Cellular Mechanisms and Pathological Outcomes","volume":"10","author":"Wilkinson","year":"2020","journal-title":"Open Biol."},{"key":"2026101904074534700_cit54","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00419","article-title":"The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-Wound Healing Phenotypes","volume":"9","author":"Krzyszczyk","year":"2018","journal-title":"Front. Physiol."},{"key":"2026101904074534700_cit55","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1284981","article-title":"Research Progress on the Mechanism of Angiogenesis in Wound Repair and Regeneration","volume":"14","author":"Shi","year":"2023","journal-title":"Front. Physiol."},{"issue":"1","key":"2026101904074534700_cit56","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41392-025-02249-0","article-title":"Vascular Endothelial Growth Factor Signaling in Health and Disease: From Molecular Mechanisms to Therapeutic Perspectives","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"2026101904074534700_cit57","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12091939","article-title":"Novel Factors Regulating Proliferation, Migration, and Differentiation of Fibroblasts, Keratinocytes, and Vascular Smooth Muscle Cells during Wound Healing","volume":"12","author":"Smith","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"2026101904074534700_cit58","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1007\/s11033-024-09750-9","article-title":"Extracellular Matrix-Inspired Biomaterials for Wound Healing","volume":"51","author":"Hosty","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"2026101904074534700_cit59","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/sj.jid.5700701","article-title":"Inflammation in Wound Repair: Molecular and Cellular Mechanisms","volume":"127","author":"Eming","year":"2007","journal-title":"J. Investig. Dermatol."},{"issue":"21","key":"2026101904074534700_cit60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111579","article-title":"An Update on Molecular Mechanisms of Scarring\u2014A Narrative Review","volume":"25","author":"Kohlhauser","year":"2024","journal-title":"Int. J. Mol. Sci."}],"container-title":["ACS Applied Bio Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsabm.6c01087","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/doi\/10.1021\/acsabm.6c01087\/68768066\/mt-2026-01087h.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article-pdf\/doi\/10.1021\/acsabm.6c01087\/68768066\/mt-2026-01087h.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:29:56Z","timestamp":1792398596000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aabmcb\/article\/9\/20\/9628\/5445907\/Bioactive-Chitosan-Membranes-Loaded-with-Nile"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":60,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2026,10,7]]},"published-print":{"date-parts":[[2026,10,19]]}},"URL":"https:\/\/doi.org\/10.1021\/acsabm.6c01087","relation":{},"ISSN":["2576-6422"],"issn-type":[{"value":"2576-6422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}