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Herein, we present a biodegradable and multifunctional nanotherapeutic platform constructed by encapsulating manganese-doped carbon dots (MnCDs) within the zinc-based metal\u2212organic framework (MOF)-ZIF-8 and further embedding the composite into a K-Carrageenan (K-Car) biopolymeric hydrogel matrix, referred to as the MnCD@ZIF-8@K-Car gel. This nanoplatform was designed for the efficient encapsulation of the anticancer drug 5-fluorouracil (5 FU) and exhibited a pronounced pH-responsive drug release profile under tumor-mimicking acidic conditions. The MnCD@ZIF-8@K-Car system demonstrated intense blue fluorescence, enabling effective in vitro fluorescence imaging, and exhibited excellent T1\u2212T2-weighted MRI contrast enhancement at low concentrations. Moreover, the nanocomposite catalyzed Fenton-like reactions with endogenous hydrogen peroxide in the microenvironment, producing highly reactive hydroxyl radicals that induce oxidative damage to intracellular biomolecules and suppress tumor cell proliferation. In addition, the ZIF-8 imparted notable bacteriostatic activity against Gram-negative Escherichia coli. Cellular internalization and cytotoxicity investigations revealed selective toxicity toward folate-receptor-overexpressing HeLa cells, while comparatively reduced cytotoxic effects were observed in MDA-MB-231 breast cancer cells and nonmalignant L929 fibroblasts. Overall, this multifunctional MnCD@ZIF-8@K-Car nanohydrogel integrates pH-responsive chemotherapy, chemodynamic therapy, biosensing, dual-modal imaging, and antibacterial functionality within a single system, highlighting its strong potential for advanced cancer theranostic applications.<\/jats:p>","DOI":"10.1021\/acsabm.6c01111","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:05:29Z","timestamp":1785920729000},"page":"7650-7670","source":"Crossref","is-referenced-by-count":0,"title":["Magneto-Fluorescent Mn-Doped CD@ZIF-8@Kappa Carrageenan Biohydrogel\u2014A Dual Model Therapeutic and Diagnostic Agent for Targeted Drug Delivery and Cancer Therapy"],"prefix":"10.1021","volume":"9","author":[{"given":"Sayani","family":"Maiti","sequence":"first","affiliation":[{"name":"Indian Institute of Technology Kharagpur , , ,","place":["Kharagpur, India, 721302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debjit","family":"Maity","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Kharagpur , , ,","place":["Kharagpur, India, 721302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-2544","authenticated-orcid":true,"given":"Agnishwar","family":"Girigoswami","sequence":"additional","affiliation":[{"name":"Chettinad Academy of Research and Education (CARE) , , Kelambakkam, ,","place":["Chennai, India, TN-603103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-3323","authenticated-orcid":true,"given":"Mahitosh","family":"Mandal","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Kharagpur , , ,","place":["Kharagpur, India, 721302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan Chandra","family":"Das","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Kharagpur , , ,","place":["Kharagpur, India, 721302"]},{"name":"Indian Institute of Technology Kharagpur , , ,","place":["Kharagpur, India, 721302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-3198","authenticated-orcid":true,"given":"Susanta","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Kharagpur , , ,","place":["Kharagpur, India, 721302"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"3","key":"2026081707160135400_cit1","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1021\/acsomega.6b00385","article-title":"Metal-Organic Framework\/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy","volume":"2","author":"Tian","year":"2017","journal-title":"ACS Omega"},{"issue":"1","key":"2026081707160135400_cit2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.64048\/v4653v12","article-title":"Immuno-Gene Therapies in Oncology: A New Era Beyond Chemotherapy","volume":"1","author":"Hamid","year":"2025","journal-title":"Heal. 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